Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 11/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863618 | 0.91 | MMP1 (0.45) | RORCTBXAS1NAMPTTDP1POLB | |
| SCHEMBL328658 | 0.82 | HSP90AA1 (0.41) | TBXAS1TBXA2RTDP1ALDH1A1 | |
| SCHEMBL6851737 | 0.81 | TDP1 (0.41) | TDP1KMT2A | |
| SCHEMBL328473 | 0.81 | F13A1 (0.41) | — | |
| SCHEMBL328478 | 0.80 | LMNA (0.35) | — | |
| SCHEMBL328414 | 0.79 | DAGLA (0.37) | POLBALDH1A1KMT2A | |
| SCHEMBL328412 | 0.78 | MMP3 (0.37) | KMT2A | |
| SCHEMBL6850285 | 0.78 | MMP13 (0.41) | RORCTBXAS1TBXA2RTDP1POLB | |
| SCHEMBL6850664 | 0.78 | DAGLA (0.43) | POLBALDH1A1 | |
| SCHEMBL328661 | 0.78 | KMT2A (0.38) | TDP1POLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |