Pyridine

Pyridine

SCHEMBL6864644

Cc1cccc(C)n1.c1ccncc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.52
CCR8 P51685 1/20 0.52
CYP2A6 P11509 1/20 0.50
GRM5 P41594 5/20 0.48
NOS3 P29474 1/20 0.48
NOS2 P35228 1/20 0.48
TSHR P16473 2/20 0.47
NAPRT Q6XQN6 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
RAB9A P51151 4/20 0.42
ALDH1A1 P00352 4/20 0.42
NPC1 O15118 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
KDM4E B2RXH2 3/20 0.42
HPGD P15428 3/20 0.42
HDAC6 Q9UBN7 2/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2D6 P10635 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyridine SCHEMBL28335243 0.97 CCR1 (0.50) CCR1CCR8CYP2A6GRM5NOS3
Pyridine SCHEMBL4589889 0.89 GRM5 (0.52) CCR1CCR8CYP2A6GRM5NOS3
Pyridine SCHEMBL28172263 0.85 GRM5 (0.41) CCR1CCR8CYP2A6GRM5NOS3
Pyridine SCHEMBL28169149 0.84 ALDH1A1 (0.47) CYP2A6GRM5TSHRRAB9AALDH1A1
Hydrochloric Acid SCHEMBL14965070 0.83 CCR1 (0.63) CCR1CCR8CYP2A6GRM5NOS3
SCHEMBL9611 0.83
SCHEMBL30421349 0.83
SCHEMBL1771685 0.83 CCR1 (0.71) CCR1CCR8CYP2A6GRM5NOS3
Hydrochloric Acid SCHEMBL15145084 0.80 CCR1 (0.60) CCR1CCR8CYP2A6GRM5NOS3
SCHEMBL184761 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1973919-B1 ONE POT SYNTHESIS OF TETRAZOLE DERIVATIVES OF SIROLIMUS ABBOTT LAB (US) 2014-09-03 EP claimed
CN-113874402-B Polar group-containing olefin copolymer 国立大学法人东京大学 2023-04-04 CN disclosed
US-20230002383-A1 NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE PRAEVENTIX, LLC 2023-01-05 US disclosed
EP-4058455-A1 NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE Temple University - Of The Commonwealth System of Higher Education (US) 2022-09-21 EP disclosed
CN-113874402-A Polar group-containing olefin copolymer 国立大学法人东京大学 2021-12-31 CN disclosed
US-11059854-B2 Method for preparing steroid derivative FXR agonist CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2021-07-13 US disclosed
WO-2021097116-A1 NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2021-05-20 WO disclosed
EP-3790859-A1 NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE Temple University - Of The Commonwealth System of Higher Education (US) 2021-03-17 EP disclosed
EP-3761985-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE Temple University - Of The Commonwealth System of Higher Education (US) 2021-01-13 EP disclosed
US-20200231622-A1 METHOD FOR PREPARING STEROID DERIVATIVE FXR AGONIST CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2020-07-23 US disclosed
WO-2019217890-A1 NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2019-11-14 WO disclosed
WO-2019173633-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2019-09-12 WO disclosed
US-9783536-B2 Nitrogen-containing heterocyclic compound or salt thereof FUJIFILM CORPORATION (JP) 2017-10-10 US disclosed
EP-2944637-A1 NITROGEN-CONTAINING HETEROCYLIC COMPOUND OR SALT THEREOF FUJIFILM Corporation (JP) 2015-11-18 EP disclosed
US-20150322063-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF FUJIFILM CORPORATION (JP) 2015-11-12 US disclosed
EP-1718629-B1 Benzopyran compounds useful for the treatment of arrhytmia NISSAN CHEMICAL IND LTD (JP) 2012-12-26 EP disclosed
CN-1191235-C Process for preparing substd. pyridines compounds PFIZER PROD INC (US) 2005-03-02 CN disclosed
EP-1405852-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-07 EP disclosed
CN-1320596-A Process for preparing substd. pyridines compounds PFIZER PROD INC (US) 2001-11-07 CN disclosed
US-4093522-A WITH WATER SOLUBLE PYRIDINIUM, QUINOLINIUM OR ACRIDINIUM SULFATE AND HALIDE DILLENBERG HORST 1978-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11059854-B2 Method for preparing steroid derivative FXR agonist FXR1, NR1H4, FXR2 CCR1 1008/4885CCR8 704/4885CYP2A6 82/4885
US-20150322063-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF NPM1, NAP1L1, REN CCR1 316/4885CCR8 1599/4885CYP2A6 3568/4885
US-20200231622-A1 METHOD FOR PREPARING STEROID DERIVATIVE FXR AGONIST FXR1, NR1H4, FXR2 CCR1 1008/4885CCR8 704/4885CYP2A6 82/4885
US-20230002383-A1 NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE HTR7, HTR1A, HTR2C CCR1 1373/4885CCR8 628/4885CYP2A6 442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.