Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142283 | 0.85 | ALOX15 (0.43) | ADORA2AMEN1KMT2ANAMPTRAB9A | |
| SCHEMBL6868324 | 0.85 | NAMPT (0.46) | ADORA2AMEN1KMT2ANAMPTALDH1A1 | |
| SCHEMBL6868100 | 0.83 | ADORA2A (0.44) | MAPTADORA2AMEN1KMT2APOLB | |
| SCHEMBL6869047 | 0.82 | ADORA2A (0.40) | MAPTADORA2ANAMPTKDRRAB9A | |
| SCHEMBL6871320 | 0.81 | SMN1; SMN2 (0.43) | MAPTADORA2AMEN1KMT2ANAMPT | |
| SCHEMBL6868261 | 0.80 | NPC1 (0.48) | MAPTADORA2APOLBTP53RAB9A | |
| SCHEMBL6867096 | 0.79 | TP53 (0.44) | MAPTKMT2ATP53ALDH1A1LMNA | |
| SCHEMBL6867473 | 0.79 | KMT2A (0.43) | MAPTADORA2AKMT2ANAMPTTP53 | |
| SCHEMBL6870449 | 0.79 | RAB9A (0.45) | MAPTTBK1ADORA2AMEN1KMT2A | |
| SCHEMBL6868483 | 0.78 | ADORA2A (0.64) | ADORA2AKDRPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |