Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869842 | 0.88 | PLAU (0.48) | ADORA2APLAUALOX5ALDH1A1RAB9A | |
| SCHEMBL6868483 | 0.85 | ADORA2A (0.64) | ADORA2APLAU | |
| SCHEMBL6870681 | 0.84 | ADORA2A (0.49) | ADORA2AALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL6863751 | 0.84 | ADORA2A (0.62) | ADORA2AALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL6868263 | 0.83 | MAPT (0.46) | ADORA2APLAUALOX5ALDH1A1RAB9A | |
| SCHEMBL6870449 | 0.83 | RAB9A (0.45) | ADORA2APLAUALDH1A1RAB9ALMNA | |
| SCHEMBL6869736 | 0.82 | ADORA2A (0.48) | ADORA2A | |
| SCHEMBL6873045 | 0.82 | ADORA2A (0.62) | ADORA2AMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6871948 | 0.82 | HDAC2 (0.46) | ADORA2AALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL6867554 | 0.82 | ADORA2A (0.63) | ADORA2AALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |