Sugi Predict

Sugi Predict / Compounds / SCHEMBL6869759

SCHEMBL6869759

SCHEMBL6869759

CCOC(=O)C1CCN(c2ccnc(Cl)n2)CC1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.57
▸ CYP2C19 P33261 1/20 0.53
▸ KMT2A Q03164 3/20 0.51
▸ SHMT2 P34897 1/20 0.50
▸ ALDH1A1 P00352 6/20 0.47
▸ KDM4E B2RXH2 4/20 0.47
▸ TSHR P16473 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ LGMN Q99538 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ ALOX12 P18054 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2635948 0.86 ALDH1A1 (0.54) CYP2C19SHMT2ALDH1A1KDM4ETSHR
SCHEMBL12185358 0.86 ALDH1A1 (0.54) CYP2C19SHMT2ALDH1A1KDM4ETSHR
SCHEMBL29438234 0.86 ALDH1A1 (0.54) CYP2C19SHMT2ALDH1A1KDM4ETSHR
SCHEMBL4018974 0.86 SMN1; SMN2 (0.61) MAPTKMT2AKDM4ESMN1; SMN2MEN1
SCHEMBL23582102 0.85 HRH3 (0.56) MAPTCYP2C19KMT2ASHMT2ALDH1A1
SCHEMBL31357649 0.85 HRH3 (0.56) MAPTCYP2C19KMT2ASHMT2ALDH1A1
SCHEMBL23582305 0.83 TRPV1 (0.43) MAPTALDH1A1
SCHEMBL14811862 0.83 KMT2A (0.59) MAPTCYP2C19KMT2ASHMT2ALDH1A1
SCHEMBL31557346 0.81 MAPT (0.58) MAPTCYP2C19KMT2ASHMT2ALDH1A1
SCHEMBL31357698 0.81 MAPT (0.61) MAPTCYP2C19KMT2ASHMT2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630528-B2 Amino aryl derivative useful as diacylglycerol acyltransferase 2 inhibitor and use thereof LG CHEM, LTD. (KR) 2026-05-19 — — US disclosed
EP-4071147-B1 NOVEL AMINO ARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND USE THEREOF LG CHEMICAL LTD (KR) 2025-03-26 — — EP disclosed
US-20250026749-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2025-01-23 — — US disclosed
CN-114846013-B Novel aminoaryl derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof 株式会社LG化学 2024-12-20 — — CN disclosed
US-12060349-B2 Glucosylceramide synthase inhibitors GENZYME CORPORATION (US) 2024-08-13 — — US disclosed
US-20230078941-A1 NOVEL AMINO ARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND USE THEREOF LG CHEM, LTD. (KR) 2023-03-16 — — US disclosed
EP-4098654-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Genzyme Corporation (US) 2022-12-07 — — EP disclosed
EP-4071147-A1 NOVEL AMINO ARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND USE THEREOF Lg Chem, Ltd. (KR) 2022-10-12 — — EP disclosed
CN-114846013-A Novel aminoaryl derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof 株式会社LG化学 2022-08-02 — — CN disclosed
CN-114533729-A Glucosylceramide synthase inhibitors 建新公司 2022-05-27 — — CN disclosed
US-8993757-B2 N-piperidin-4-yl derivatives MERCK SHARP & DOHME B.V. (NL) 2015-03-31 — — US disclosed
US-20140329822-A1 N-PIPERIDIN-4-YL DERIVATIVES MERCK SHARP & DOHME B.V. (NL) 2014-11-06 — — US disclosed
WO-2014043068-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2014-03-20 — — WO disclosed
WO-2013041457-A1 N-PIPERIDIN-4-YL DERIVATIVES MSD OSS B.V. (NL) 2013-03-28 — — WO disclosed
WO-2010015653-A1 PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE SMITHKLINE BEECHAM CORPORATION (US) 2010-02-11 — — WO disclosed
US-6812231-B2 INHIBITING ACTIVATED BLOOD-COAGULATION FACTOR X AJINOMOTO CO., INC. (JP) 2004-11-02 — — US disclosed
US-20020107290-A1 Benzamidine derivative AJINOMOTO CO., INC. (JP) 2002-08-08 — — US disclosed
US-6410538-B2 ANTICOAGULANT OR AN AGENT FOR TREATING OR PREVENTING THROMBI OR EMBOLI AJINOMOTO CO., INC. (JP) 2002-06-25 — — US disclosed
US-20010056123-A1 Anticoagulant or an agent for treating or preventing thrombi or emboli AJINOMOTO CO., INC (JP) 2001-12-27 — — US disclosed
EP-1086946-A1 BENZAMIDINE DERIVATIVE Ajinomoto Co., Inc. (JP) 2001-03-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107290-A1 Benzamidine derivative SERPINE1, SERPINC1, TFPI MAPT 4300/4885CYP2C19 179/4885KMT2A 3695/4885
US-20010056123-A1 Anticoagulant or an agent for treating or preventing thrombi or emboli SERPINC1, SERPINE1, F2 MAPT 4813/4885CYP2C19 358/4885KMT2A 4359/4885
US-12060349-B2 Glucosylceramide synthase inhibitors GBA1, GBA2, GALC MAPT 3852/4885CYP2C19 2156/4885KMT2A 2942/4885
US-20250026749-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GBA1, GBA2, GAA MAPT 4277/4885CYP2C19 2400/4885KMT2A 2721/4885
US-20230078941-A1 NOVEL AMINO ARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND USE THEREOF DGAT2, DGAT1, PLAAT2 MAPT 2601/4885CYP2C19 582/4885KMT2A 421/4885
US-12630528-B2 Amino aryl derivative useful as diacylglycerol acyltransferase 2 inhibitor and use thereof DGAT2, DGAT1, SOAT2 MAPT 4476/4885CYP2C19 811/4885KMT2A 889/4885
US-20140329822-A1 N-PIPERIDIN-4-YL DERIVATIVES PGR, CYP19A1, BRCA1 MAPT 4046/4885CYP2C19 150/4885KMT2A 437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.