Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868100 | 0.88 | ADORA2A (0.44) | PLAUADORA2AALDH1A1KDM4EMEN1 | |
| SCHEMBL6869746 | 0.85 | PLAU (0.43) | PLAUMAP3K5ADORA2AALDH1A1KDM4E | |
| SCHEMBL6863099 | 0.84 | ADORA2A (0.45) | MAP3K5ADORA2A | |
| SCHEMBL6871806 | 0.80 | ADORA2A (0.42) | ADORA2A | |
| SCHEMBL6870707 | 0.79 | KMT2A (0.43) | MAP3K5ADORA2AALDH1A1MAPTKMT2A | |
| SCHEMBL6863096 | 0.79 | SMN1; SMN2 (0.43) | ADORA2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL6870530 | 0.78 | ADORA2A (0.43) | ADORA2AALDH1A1KDM4EMEN1POLB | |
| SCHEMBL6869838 | 0.78 | ADORA2A (0.43) | ADORA2AALDH1A1KDM4EMEN1USP2 | |
| SCHEMBL6868483 | 0.78 | ADORA2A (0.64) | PLAUF2KCNK3KCNK9ADORA2A | |
| SCHEMBL6867554 | 0.78 | ADORA2A (0.63) | ADORA2AALDH1A1MEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |