Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873511 | 0.76 | GPR88 (0.57) | RAB9AMAPK1HTTGPR88 | |
| SCHEMBL12929971 | 0.73 | ATM (0.44) | SMN1; SMN2NPC1RAB9AMAPK1ALDH1A1 | |
| SCHEMBL12961032 | 0.70 | ATM (0.42) | SMN1; SMN2NPC1RAB9AMAPK1ALDH1A1 | |
| SCHEMBL465084 | 0.68 | ALDH1A1 (0.56) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL2563160 | 0.68 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL2818747 | 0.67 | ATM (0.50) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL427541 | 0.67 | ATM (0.68) | SMN1; SMN2ALDH1A1POLBPPARGPPARA | |
| SCHEMBL465047 | 0.67 | GABRA1 (0.49) | SMN1; SMN2NPC1RAB9AMAPK1ALDH1A1 | |
| SCHEMBL465065 | 0.66 | PPARG (0.58) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL17527230 | 0.66 | ALOX5 (0.48) | SMN1; SMN2NPC1RAB9AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044195-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |