Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10387270 | 0.88 | CHRM4 (0.43) | KCNH2GAATP53CHRM4THRB | |
| Fumaric Acid SCHEMBL10387272 | 0.88 | CHRM4 (0.43) | KCNH2GAATP53CHRM4THRB | |
| SCHEMBL6870263 | 0.84 | SIGMAR1 (0.45) | SIGMAR1TP53THRBADRA2AADRA2B | |
| SCHEMBL10397351 | 0.77 | PRMT5 (0.56) | HTR1ALMNAPRMT5WDR77 | |
| SCHEMBL10819390 | 0.73 | SIGMAR1 (0.66) | SIGMAR1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL10899537 | 0.71 | L3MBTL1 (0.48) | GAAL3MBTL1 | |
| SCHEMBL5440637 | 0.69 | TP53 (0.55) | GAATP53THRBDRD2LMNA | |
| SCHEMBL10899544 | 0.69 | L3MBTL1 (0.50) | GAAL3MBTL1 | |
| SCHEMBL12897404 | 0.68 | CHRM4 (0.60) | KCNH2GAACHRM4L3MBTL1LMNA | |
| Hydrochloric Acid SCHEMBL10385455 | 0.68 | ACHE (0.47) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019408-B1 | 1,2,3,4-TETRAHYDRO-BENZOFURO[3,2-c]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-30 | — | — | EP | disclosed |
| US-6156757-A | 1,2,3,4-tetrahydro-benzofuro[3,2-C]pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-12-05 | — | — | US | disclosed |
| EP-1019408-A1 | 1,2,3,4-TETRAHYDRO-BENZOFURO 3,2-c]PYRIDINE DERIVATIVES-- | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998045297-A1 | 1,2,3,4-TETRAHYDRO-BENZOFURO[3,2-c]PYRIDINE DERIVATIVES__ | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-10-15 | — | — | WO | disclosed |