Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.39 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10387270 | 1.00 | CHRM4 (0.43) | CHRM4CHRM1HDAC1KCNH2GAA | |
| SCHEMBL6871964 | 0.88 | SIGMAR1 (0.47) | CHRM4KCNH2GAALMNATP53 | |
| Hydrochloric Acid SCHEMBL10385455 | 0.74 | ACHE (0.47) | — | |
| SCHEMBL10397351 | 0.74 | PRMT5 (0.56) | HDAC1LMNAPRMT5WDR77HTR1A | |
| SCHEMBL6870263 | 0.73 | SIGMAR1 (0.45) | HDAC1LMNATP53THRBMEN1 | |
| Fumaric Acid SCHEMBL10414108 | 0.68 | DRD2 (0.54) | HDAC1GAALMNATP53HTR1A | |
| Fumaric Acid SCHEMBL10414107 | 0.68 | DRD2 (0.54) | HDAC1GAALMNATP53HTR1A | |
| SCHEMBL2978467 | 0.67 | HDAC1 (0.47) | HDAC1GAALMNATP53 | |
| SCHEMBL10899537 | 0.67 | L3MBTL1 (0.48) | GAABRD4MEN1KMT2A | |
| SCHEMBL5507692 | 0.67 | MTHFD2 (0.52) | HDAC1GAALMNATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931449-A | 2-((4-piperidyl)methyl)benzofuro(2,3-C)pyridine derivatives, and their application in therapy | SYNTHELABO (FR) | 1990-06-05 | — | — | US | disclosed |