Metofurone

Metofurone

SCHEMBL687311

O=C(Cl)c1ccc([N+](=O)[O-])o1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.54
ALDH1A1 P00352 3/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
LMNA P02545 5/20 0.53
HTT P42858 2/20 0.53
NPC1 O15118 3/20 0.53
MITF O75030 2/20 0.53
KMT2A Q03164 3/20 0.51
MEN1 O00255 2/20 0.51
GAA P10253 2/20 0.51
KDM4E B2RXH2 1/20 0.51
USP2 O75604 1/20 0.51
GLA P06280 1/20 0.51
RXFP1 Q9HBX9 1/20 0.51
PAX8 Q06710 1/20 0.51
NFKB1 P19838 1/20 0.50
NFKB2 Q00653 1/20 0.50
RELA Q04206 1/20 0.50
MAPT P10636 2/20 0.49
POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Metofurone SCHEMBL7733994 0.84 LMNA (0.47) RAB9AALDH1A1L3MBTL1LMNAHTT
SCHEMBL11407927 0.83 LMNA (0.56) RAB9AALDH1A1L3MBTL1LMNAHTT
5-Nitro-2-Furoic Acid SCHEMBL1221377 0.82 LMNA (0.58) RAB9AALDH1A1L3MBTL1LMNAHTT
SCHEMBL1199803 0.80 L3MBTL1 (0.55) RAB9AALDH1A1L3MBTL1LMNAHTT
SCHEMBL6734715 0.80 MAPT (0.60) RAB9AALDH1A1L3MBTL1LMNAHTT
5-Nitro-2-Furoic Acid SCHEMBL2115021 0.80 LMNA (0.57) RAB9AALDH1A1L3MBTL1LMNAHTT
SCHEMBL6352334 0.80 LMNA (0.53) RAB9AALDH1A1L3MBTL1LMNAHTT
Nifurmerone SCHEMBL398798 0.79 LMNA (0.51) RAB9AALDH1A1L3MBTL1LMNAHTT
SCHEMBL5925722 0.78 MAPT (0.59) ALDH1A1L3MBTL1LMNAHTTNPC1
SCHEMBL11689214 0.78 LMNA (0.55) RAB9AALDH1A1L3MBTL1LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119874697-A Preparation method of thiazole amide derivative and application of thiazole amide derivative in treatment of inflammation 成都大学 2025-04-25 CN claimed
CN-114085215-B Fumaric acid amide compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof 南方医科大学 2023-07-25 CN claimed
CN-112341448-B Fluorescent probe and preparation method and application thereof 山东师范大学 2022-04-15 CN claimed
CN-114085215-A Fumaric acid amide compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof 南方医科大学 2022-02-25 CN claimed
CN-112341448-A Fluorescent probe and preparation method and application thereof 山东师范大学 2021-02-09 CN claimed
US-20160175303-A1 SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-06-23 US claimed
US-20120095021-A1 SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH 2012-04-19 US claimed
US-20030166645-A1 Novel nitrofuran-containing heterocyclic compounds and uses thereof ALA PAUL J (US) 2003-09-04 US claimed
WO-2003000255-A1 NOVEL NITROFURAN-CONTAINING HETEROCYCLIC COMPOUNDS AND USES THEREOF ESSENTIAL THERAPEUTICS, INC. (US) 2003-01-03 WO claimed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 EP claimed
CN-122036604-A Compound and application thereof 中国药科大学 2026-05-15 CN disclosed
US-20260125356-A1 TREATMENT OF LEISHMANIASIS THE UNIV OF DURHAM (GB) 2026-05-07 US disclosed
EP-4605086-A1 TREATMENT OF LEISHMANIASIS The University of Durham (GB) 2025-08-27 EP disclosed
CN-119874697-A Preparation method of thiazole amide derivative and application of thiazole amide derivative in treatment of inflammation 成都大学 2025-04-25 CN disclosed
CN-119874697-A Preparation method of thiazole amide derivative and application of thiazole amide derivative in treatment of inflammation 成都大学 2025-04-25 CN disclosed
US-3982922-A Herbicidal compositions containing furancarboxamides VELSICOL CHEMICAL CORPORATION (US) 1976-09-28 US disclosed
US-3978075-A Substituted carbamoyl benzimidazole derivatives with antifungal properties CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT (HU) 1976-08-31 US disclosed
US-3964894-A 1-(FURYL OR THIAZOLYL)CARBONYL-2-METHYL-5-METHOXY-INDOL-3-YL ACETIC ACID CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT (HU) 1976-06-22 US disclosed
US-3957766-A BACTERIOSTATS, BACTERICIDES BOEHRINGER MANNHEIM G.M.B.H. (DT) 1976-05-18 US disclosed
US-3954744-A ANTIBACTERIAL E. R. SQUIBB & SONS, INC. (US) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160175303-A1 SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS TST, TBCA, SDHA RAB9A 2476/4885ALDH1A1 782/4885L3MBTL1 3523/4885
US-20120095021-A1 SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS TST, SDHB, SDHA RAB9A 4194/4885ALDH1A1 1613/4885L3MBTL1 2870/4885
US-20030166645-A1 Novel nitrofuran-containing heterocyclic compounds and uses thereof NQO1, NOX5, NISCH RAB9A 3056/4885ALDH1A1 763/4885L3MBTL1 3334/4885
US-20260125356-A1 TREATMENT OF LEISHMANIASIS NR1H2, NR1H3, MSR1 RAB9A 2312/4885ALDH1A1 1031/4885L3MBTL1 469/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.