Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.48 |
| ▸ | FEN1 | P39748 | 7/20 | 0.48 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20628137 | 0.83 | ALOX5AP (0.46) | KIF11ALOX5APFEN1HCRTR1HCRTR2 | |
| SCHEMBL1744740 | 0.80 | ALOX5AP (0.55) | ALOX5APFEN1TRPV1 | |
| SCHEMBL9117010 | 0.78 | KIF11 (0.39) | KIF11ALOX5APFEN1PTGES2HCRTR1 | |
| SCHEMBL16177988 | 0.77 | PTGS2 (0.50) | ALOX5APFEN1LMNA | |
| SCHEMBL28510482 | 0.76 | CYP11B1 (0.43) | KIF11ALOX5APFEN1KMT2AKDM4E | |
| SCHEMBL2567683 | 0.76 | KIF11 (0.56) | KIF11ALOX5APFEN1PTGES2TRPV1 | |
| SCHEMBL31114170 | 0.76 | CYP11B1 (0.43) | KIF11ALOX5APFEN1KMT2AKDM4E | |
| SCHEMBL16915425 | 0.76 | HSD17B10 (0.48) | KIF11ALOX5APFEN1LMNAKMT2A | |
| SCHEMBL31114090 | 0.76 | CASP3 (0.44) | KIF11LMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL16180470 | 0.75 | ALOX5AP (0.47) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108094-A2 | SULFONAMIDE-SUBSTITUTED CHALCONE DERIVATIVES AND THEIR USE TO TREAT DISEASES | ATHEROGENICS, INC. (US) | 2004-12-16 | — | — | WO | disclosed |