Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6883452 | 0.93 | PTGS1 (0.43) | PTGS1PTGS2LMNAHDAC3TSHR | |
| Benzoquinone SCHEMBL10412922 | 0.72 | GLRA1 (0.59) | PTGS1PTGS2LMNATHRBBLM | |
| Adipic Acid SCHEMBL15658059 | 0.67 | LMNA (0.73) | LMNATHRBBLMKMT2ANPSR1 | |
| Benzoquinone SCHEMBL27728283 | 0.66 | BLM (0.46) | PTGS1PTGS2LMNATHRBBLM | |
| Azelaic Acid SCHEMBL28076544 | 0.65 | TSHR (0.75) | LMNATHRBBLMKMT2ANPSR1 | |
| Glycine SCHEMBL28855970 | 0.65 | TSHR (0.75) | LMNATHRBBLMKMT2ANPSR1 | |
| Azelaic Acid SCHEMBL28549989 | 0.65 | TSHR (0.75) | LMNATHRBBLMKMT2ANPSR1 | |
| Succinic Acid SCHEMBL7413466 | 0.65 | LMNA (0.56) | PTGS1PTGS2LMNABLMKMT2A | |
| Adipic Acid SCHEMBL541841 | 0.63 | NFKB1 (0.65) | LMNATHRBBLMKMT2ANPSR1 | |
| Gamma-Aminobutyric Acid SCHEMBL297249 | 0.63 | LMNA (0.88) | LMNATHRBBLMKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087933-A2 | A NOVEL ENCODING METHOD FOR 'ONE-BEAD ONE-COMPOUND' COMBINATORIAL LIBRARIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-10-14 | — | — | WO | disclosed |