Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 6/20 | 0.32 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6885577 | 0.86 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL6878729 | 0.85 | FFAR1 (0.37) | FFAR1PTGES | |
| SCHEMBL6158466 | 0.79 | NOS1 (0.37) | FFAR1 | |
| SCHEMBL6885341 | 0.73 | ACACB (0.43) | — | |
| SCHEMBL2108198 | 0.73 | FFAR1 (0.39) | HMGCRVDRCYP24A1FFAR1PTGES | |
| SCHEMBL6885245 | 0.71 | HMGCR (0.47) | HMGCRVDRCYP24A1 | |
| SCHEMBL6156152 | 0.71 | HMGCR (0.47) | HMGCRVDRCYP24A1 | |
| SCHEMBL16747415 | 0.70 | HMGCR (0.43) | HMGCRVDRCYP24A1FFAR1 | |
| SCHEMBL7775051 | 0.69 | HMGCR (0.34) | HMGCRVDRCYP24A1FFAR1PTGES | |
| SCHEMBL16747538 | 0.69 | HMGCR (0.44) | HMGCRVDRCYP24A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |
| EP-1124779-A1 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026167-A1 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2000-05-11 | — | — | WO | disclosed |