Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 4/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8589276 | 1.00 | YAP1 (0.46) | YAP1ITGB3ITGA2BACEBCL2 | |
| SCHEMBL8589279 | 0.83 | HTR2C (0.43) | YAP1ACEHTR2CSLC6A4NPY5R | |
| SCHEMBL29397771 | 0.79 | ITGB3 (0.55) | YAP1ITGB3ITGA2BMAOB | |
| SCHEMBL16634946 | 0.79 | ITGB3 (0.55) | YAP1ITGB3ITGA2BMAOB | |
| SCHEMBL6474783 | 0.79 | ITGB3 (0.55) | YAP1ITGB3ITGA2BMAOB | |
| SCHEMBL6890932 | 0.78 | PSMB1 (0.49) | BCL2RENMAOBPSMB1PSMB8 | |
| SCHEMBL6890928 | 0.78 | PSMB1 (0.49) | BCL2RENMAOBPSMB1PSMB8 | |
| SCHEMBL18918265 | 0.78 | LTA4H (0.52) | YAP1ITGB3ITGA2BBCL2MAOB | |
| Trifluoroacetic Acid SCHEMBL8645040 | 0.77 | MMP9 (0.48) | YAP1ITGB3ITGA2BACEBCL2 | |
| SCHEMBL6892246 | 0.77 | MAOB (0.44) | YAP1ITGB3ITGA2BBCL2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737410-B1 | SMOOTH MUSCLE ANTIPROLIFERATION AGENTS; SUCH AS 1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-METHYL-CARBAMOYL)-2 -(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-6265382-B1 | E.G., (S--(R*, R*))-(1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-M ETHYL-CARBAM OYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-07-24 | — | — | US | disclosed |