Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25367378 | 0.82 | AKR1B1 (0.41) | AKR1B1NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL31148302 | 0.80 | AKR1B1 (0.39) | AKR1B1NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL25360558 | 0.80 | AKR1B1 (0.39) | AKR1B1NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL6908063 | 0.79 | GABRA1 (0.43) | TAAR1LMNACYP3A4HTR1AALDH1A1 | |
| SCHEMBL91356 | 0.78 | TAAR1 (0.50) | AKR1B1SMN1; SMN2KMT2AHTTTAAR1 | |
| SCHEMBL26027265 | 0.78 | NOS3 (0.34) | NOS3NOS2KMT2AHTTLMNA | |
| SCHEMBL22588432 | 0.76 | GABRA1 (0.50) | AKR1B1NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL3790392 | 0.74 | GABRA1 (0.46) | AKR1B1SMN1; SMN2KMT2AHTTTAAR1 | |
| SCHEMBL6829665 | 0.72 | AKR1B1 (0.43) | AKR1B1SMN1; SMN2KMT2AHTTTAAR1 | |
| SCHEMBL14256813 | 0.72 | POLB (0.50) | SMN1; SMN2KMT2AHTTADRA2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172264-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | ASTRAEA THERAPEUTICS, LLC | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172264-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA4, CHRNA3, CHRNA6 | AKR1B1 1697/4885NOS3 1211/4885NOS1 2387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.