Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 10/20 | 0.44 |
| ▸ | HAT1 | O14929 | 9/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889436 | 0.90 | SIGMAR1 (0.49) | CYP1A2CYP2D6CYP2C19POLBLMNA | |
| SCHEMBL7636221 | 0.87 | POLB (0.50) | CYP2D6CYP2C19EP300HAT1KMT2A | |
| SCHEMBL6894820 | 0.86 | CYP1A2 (0.60) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL6891363 | 0.85 | KMT2A (0.55) | EP300HAT1KMT2AMEN1 | |
| SCHEMBL6887458 | 0.82 | SIGMAR1 (0.51) | CYP2D6CYP2C19KMT2A | |
| SCHEMBL6893114 | 0.78 | SIGMAR1 (0.42) | POLBOPRK1 | |
| SCHEMBL6894568 | 0.77 | CYP3A4 (0.44) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL3649450 | 0.77 | TACR1 (0.46) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL6895745 | 0.76 | LMNA (0.47) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL6890574 | 0.75 | PLA2G1B (0.52) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |