Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894924 | 0.84 | KDM4E (0.43) | ADRA2ALMNAALDH1A1ANPEPAOC3 | |
| SCHEMBL6889436 | 0.83 | SIGMAR1 (0.49) | CYP3A4ADRA2ALMNACYP1A2CYP2D6 | |
| SCHEMBL6895074 | 0.82 | HPGD (0.44) | ADRA2ALMNAALDH1A1ANPEPAOC3 | |
| SCHEMBL6895263 | 0.81 | KDM4E (0.43) | ADRA2ALMNACYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL6887458 | 0.81 | SIGMAR1 (0.51) | CYP2D6CYP2C19KCNH2KMT2ACNR1 | |
| SCHEMBL6890858 | 0.80 | SIGMAR1 (0.50) | LMNACYP2D6HTR1AADRA1ADRD3 | |
| SCHEMBL6896045 | 0.80 | ALDH1A1 (0.49) | ADRA2ALMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6895745 | 0.79 | LMNA (0.47) | ADRA2ALMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6896012 | 0.79 | PSEN1 (0.30) | HTR2A | |
| SCHEMBL6890899 | 0.79 | AOC3 (0.36) | ADRA2ALMNAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |