Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | HAT1 | O14929 | 2/20 | 0.46 |
| ▸ | EP300 | Q09472 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889436 | 0.88 | SIGMAR1 (0.49) | SMN1; SMN2ATMSIGMAR1ALDH1A1ANPEP | |
| SCHEMBL6886251 | 0.87 | TDP1 (0.52) | KMT2AMEN1SMN1; SMN2KDM4EGAA | |
| SCHEMBL7636221 | 0.85 | POLB (0.50) | KMT2AMEN1KDM4EALDH1A1HAT1 | |
| SCHEMBL6890175 | 0.85 | CYP1A2 (0.48) | KMT2AMEN1HAT1EP300 | |
| SCHEMBL6887458 | 0.80 | SIGMAR1 (0.51) | KMT2ASIGMAR1 | |
| SCHEMBL6895074 | 0.79 | HPGD (0.44) | KDM4ETDP1ALDH1A1ANPEP | |
| SCHEMBL15712156 | 0.77 | SIGMAR1 (0.66) | KMT2AMEN1SMN1; SMN2KDM4EGAA | |
| SCHEMBL165645 | 0.77 | CASR (0.57) | KMT2AMEN1 | |
| SCHEMBL4692485 | 0.77 | CASR (0.57) | KMT2AMEN1 | |
| SCHEMBL6896045 | 0.76 | ALDH1A1 (0.49) | KMT2AMEN1SMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |