Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889436 | 0.91 | SIGMAR1 (0.49) | SIGMAR1CYP2D6CYP2C9CYP2C19KCNH2 | |
| SCHEMBL7636221 | 0.82 | POLB (0.50) | CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL6890175 | 0.82 | CYP1A2 (0.48) | CYP2D6CYP2C19KMT2A | |
| SCHEMBL6895745 | 0.82 | LMNA (0.47) | SIGMAR1CYP2D6CYP2C19KMT2A | |
| SCHEMBL6896045 | 0.82 | ALDH1A1 (0.49) | KMT2A | |
| SCHEMBL28380769 | 0.82 | SIGMAR1 (0.60) | SIGMAR1EPHX2KMT2AKCNH2 | |
| SCHEMBL6894568 | 0.81 | CYP3A4 (0.44) | CYP2D6CYP2C19KMT2ACNR1KCNH2 | |
| SCHEMBL6891363 | 0.80 | KMT2A (0.55) | SIGMAR1KMT2A | |
| SCHEMBL6893114 | 0.79 | SIGMAR1 (0.42) | SIGMAR1KCNH2 | |
| SCHEMBL6895074 | 0.78 | HPGD (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |