Bromide

Bromide

SCHEMBL6890863

Br.CN1[C@@H]2CCC[C@@]1(Cc1ccccc1)CC2

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
SLC18A2 Q05940 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.36
BCHE P06276 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3979443 0.98 HRH3 (0.38) KDM4EHRH3SLC18A2MAOAMAOB
SCHEMBL5098889 0.75 OPRM1 (0.37) HRH3MAOAMAOBALDH1A1TSHR
SCHEMBL4591916 0.73 KDM4E (0.43) KDM4EALDH1A1
SCHEMBL14755359 0.71
SCHEMBL7812135 0.71 HRH3 (0.36) HRH3SLC18A2ALDH1A1
Bromide SCHEMBL10842432 0.68 MAOA (0.44) MAOAMAOBTSHR
SCHEMBL633353 0.68 SLC6A2 (0.43)
SCHEMBL173114 0.67
SCHEMBL7327638 0.67 OPRM1 (0.31)
SCHEMBL8685284 0.66 OPRL1 (0.47) HRH3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0823936-B1 CATALYTIC CONVERSION WITH MCM-58 EXXONMOBIL OIL CORP (US) 2004-06-09 EP disclosed
EP-0823936-A4 CATALYTIC CONVERSION WITH MCM-58 MOBIL OIL CORP (US) 1999-03-10 EP disclosed
EP-0823936-A1 CATALYTIC CONVERSION WITH MCM-58 MOBIL OIL CORPORATION (US) 1998-02-18 EP disclosed
US-5614629-A QUATERNARIUM COMPOUNDS FOR TEMPLATES MOBIL OIL CORPORATION (US) 1997-03-25 US disclosed
US-5583276-A CATALYTICALLY CONVERTING FEEDSTOCK CONTAINING OLEFIN AND ISOPARAFFIN TO DISTILLATE, GASOLINE AND LUBE RANGE PRODUCTS OR MIXTURES MOBIL OIL CORPORATION (US) 1996-12-10 US disclosed
WO-1996034930-A1 CATALYTIC CONVERSION WITH MCM-58 MOBIL OIL CORPORATION (US) 1996-11-07 WO disclosed
US-5569805-A USING CRYSTALLINE CATALYST WHICH CONTAINS OXIDES OF 3 AND 4 GROUP OF PERIODIC TABLE; ALKYLATION, HYDROGENATION, TRANSALKYLATION MOBIL OIL CORPORATION (US) 1996-10-29 US disclosed
US-5534656-A ALKYLATION CATALYSTS, SYNTHETIC ZEOLITES MOBIL OIL CORPORATION (US) 1996-07-09 US disclosed
US-5527981-A USING DIFFERENTIAL SORPTION CHARACTERISTICS OF MIXTURE IN VAPOR OR LIQUID PHASE MOBIL OIL CORPORATION (US) 1996-06-18 US disclosed
US-5441721-A Synthesis of porous crystalline MCM-58 MOBIL OIL CORP. (US) 1995-08-15 US disclosed