SCHEMBL633353

SCHEMBL633353

CN1[C@@H]2CCC[C@@]1(c1ccccc1)CC2

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.43
SLC6A4 P31645 2/20 0.43
SLC6A3 Q01959 2/20 0.43
GRIN2D O15399 1/20 0.43
GRIN3B O60391 1/20 0.43
CYP2B6 P20813 1/20 0.43
PRCP P42785 1/20 0.43
GRIN1 Q05586 1/20 0.43
KCNH2 Q12809 1/20 0.43
GRIN2A Q12879 1/20 0.43
GRIN2B Q13224 1/20 0.43
GRIN2C Q14957 1/20 0.43
GRIN3A Q8TCU5 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
OPRM1 P35372 1/20 0.42
OPRD1 P41143 1/20 0.42
OPRL1 P41146 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7458612 0.85 OPRM1 (0.34) OPRM1
SCHEMBL8812050 0.83 OPRM1 (0.36) SLC6A2SLC6A4SLC6A3GRIN1GRIN2A
SCHEMBL5971560 0.83 SLC6A4 (0.35) SLC6A2SLC6A4SLC6A3KCNH2OPRM1
SCHEMBL30580699 0.83 HSD11B1 (0.37) SLC6A2SLC6A4SLC6A3KCNH2OPRM1
SCHEMBL4781128 0.83 HSD11B1 (0.34) SLC6A4GRIN1GRIN2AGRIN2B
SCHEMBL4669798 0.82 OPRK1 (0.38) SLC6A2SLC6A4SLC6A3OPRM1OPRD1
SCHEMBL7121073 0.78 OPRL1 (0.35) KCNH2GRIN2BOPRM1OPRD1OPRL1
SCHEMBL30189641 0.78 KCNH2 (0.33) SLC6A2SLC6A4SLC6A3KCNH2GRIN2B
SCHEMBL4593876 0.76 SLC6A4 (0.50) SLC6A2SLC6A4SLC6A3KCNH2
SCHEMBL11096567 0.76 OPRM1 (0.46) KCNH2OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 374 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
EP-4106872-A1 COMPOSITIONS AND METHODS FOR ASSESSING THE EFFICACY OF INHIBITORS OF NEUROTRANSMITTER TRANSPORTERS Denovo Biopharma LLC (US) 2022-12-28 EP claimed
CN-115515680-A Compositions and methods for assessing efficacy of neurotransmitter transporter inhibitors 索元生物医药有限公司 2022-12-23 CN claimed
EP-3558396-B1 DIFFERENTIAL DIAGNOSIS OF PARKINSON'S DISEASE GE HEALTHCARE LTD (GB) 2021-11-24 EP claimed
US-10980899-B2 Differential diagnosis GE HEALTHCARE LIMITED (GB) 2021-04-20 US claimed
US-20190328909-A1 DIFFERENTIAL DIAGNOSIS ACADEMIC MEDICAL CENTER (NL) 2019-10-31 US claimed
EP-3558396-A1 DIFFERENTIAL DIAGNOSIS OF PARKINSON'S DISEASE GE Healthcare Limited (GB) 2019-10-30 EP claimed
WO-2018115148-A1 DIFFERENTIAL DIAGNOSIS OF PARKINSON'S DISEASE GE HEALTHCARE LIMITED (GB) 2018-06-28 WO claimed
WO-2012056452-A2 PHARMACEUTICAL COMPOSITIONS AND DELIVERY DEVICES COMPRISING STINGING CELLS OR CAPSULES NANOCYTE (ISRAEL) LTD. (IL) 2012-05-03 WO claimed
EP-1590007-B1 IMPROVED RADIOMETAL COMPLEX COMPOSITIONS GE HEALTHCARE LTD (GB) 2010-11-10 EP claimed
US-20030109708-A1 Process for synthesizing anhydroecgonine derivative NIHON MEDI-PHYSICS CO., LTD. 2003-06-12 US claimed
WO-2003037313-A2 METHODS FOR THE TREATMENT OF ADDICTION RECOVERY PHARMACEUTICALS, INC. (US) 2003-05-08 WO claimed
US-20020159949-A1 Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level THE GENERAL HOSPITAL CORPORATION 2002-10-31 US claimed
US-20020150535-A1 Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level MADRAS BERTHA K (US) 2002-10-17 US claimed
EP-1196083-A1 IMAGING THE DOPAMINE TRANSPORTER TO DETERMINE AD-HD PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2002-04-17 EP claimed
WO-2001090716-A2 LINKER ARMS FOR NANOCRYSTALS AND COMPOUNDS THEREOF VANDERBILT UNIVERSITY (US) 2001-11-29 WO claimed
WO-2001090717-A2 LINKER ARMS FOR NANOCRYSTALS AND COMPOUNDS THEREOF VANDERBILT UNIVERSITY (US) 2001-11-29 WO claimed
US-20010020096-A1 Process for synthesizing anhydroecgonine derivative NIHON MEDI-PHYSICS CO., LTD. (JP) 2001-09-06 US claimed
EP-1127887-A1 Process for synthesizing anhydroecgonine derivative NIHON MEDI-PHYSICS Co., Ltd. (JP) 2001-08-29 EP claimed
WO-2001000082-A1 IMAGING THE DOPAMINE TRANSPORTER TO DETERMINE AD-HD PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2001-01-04 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10980899-B2 Differential diagnosis PARK7, SNCA, PSPH SLC6A2 244/4885SLC6A4 833/4885SLC6A3 51/4885
US-20190328909-A1 DIFFERENTIAL DIAGNOSIS PARK7, SNCA, PSPH SLC6A2 244/4885SLC6A4 833/4885SLC6A3 51/4885
US-20020150535-A1 Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level SLC6A3, SLC6A2, SLC18A2 SLC6A2 2/4885SLC6A4 4/4885SLC6A3 1/4885
US-20030109708-A1 Process for synthesizing anhydroecgonine derivative CES2, NPR1, OPRL1 SLC6A2 185/4885SLC6A4 908/4885SLC6A3 385/4885
US-20010020096-A1 Process for synthesizing anhydroecgonine derivative CES2, NPR1, OPRL1 SLC6A2 185/4885SLC6A4 908/4885SLC6A3 385/4885
US-20020159949-A1 Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level SLC6A3, SLC6A2, SLC18A2 SLC6A2 2/4885SLC6A4 4/4885SLC6A3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.