Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812135 | 0.72 | HRH3 (0.36) | OPRL1HRH3OPRM1HPGDEPHX1 | |
| SCHEMBL15758249 | 0.71 | SLC6A9 (0.30) | — | |
| SCHEMBL2126981 | 0.69 | LMNA (0.46) | ALDH1A1LMNA | |
| SCHEMBL1525284 | 0.68 | SMN1; SMN2 (0.54) | OPRL1OPRM1HPGDEPHX1USP2 | |
| SCHEMBL16565171 | 0.68 | METAP2 (0.51) | OPRL1OPRM1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5790059 | 0.68 | ALDH1A1 (0.40) | HPGDALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL12492886 | 0.67 | MMP8 (0.55) | OPRL1OPRM1HPGDEPHX1USP2 | |
| SCHEMBL3979443 | 0.67 | HRH3 (0.38) | HRH3ALDH1A1 | |
| SCHEMBL17107769 | 0.67 | MMP8 (0.55) | OPRL1OPRM1HPGDEPHX1USP2 | |
| SCHEMBL8685279 | 0.67 | GAA (0.66) | HRH3HPGDEPHX1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712284-A | Azalicyclooctane derivatives as anti-arrhythmic agents | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0710236-A1 | AZALICYCLOOCTANE DERIVATIVES AS ANTI-ARRHYTHMIC AGENTS | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003301-A1 | AZALICYCLOOCTANE DERIVATIVES AS ANTI-ARRHYTHMIC AGENTS | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-02-02 | — | — | WO | disclosed |
| EP-0416521-A1 | N-Benzyltropaneamides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | disclosed |