Isobutylbenzene

Isobutylbenzene

SCHEMBL6891614

CC(C)Cc1ccccc1.O

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Isobutylbenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 known ✓ Q99720 5/20 0.61
SLC6A2 known ✓ P23975 3/20 0.61
SLC6A4 known ✓ P31645 2/20 0.61
SLC6A3 known ✓ Q01959 2/20 0.61
ADORA2A known ✓ P29274 1/20 0.61
ADORA1 known ✓ P30542 1/20 0.61
HTR2A known ✓ P28223 2/20 0.50
ADRA2B known ✓ P18089 1/20 0.50
ADRA2C known ✓ P18825 1/20 0.50
ADRA1A known ✓ P35348 1/20 0.50
OPRK1 known ✓ P41145 1/20 0.50
ESR1 known ✓ P03372 1/20 0.48
ALOX5 known ✓ P09917 1/20 0.48
ADRB3 known ✓ P13945 1/20 0.48
PTGS1 known ✓ P23219 1/20 0.48
PTGS2 known ✓ P35354 1/20 0.48
TAAR1 Q96RJ0 4/20 0.61
MAOA P21397 1/20 0.61
CYP2A6 P11509 1/20 0.61
SLC18A2 Q05940 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isobutylbenzene SCHEMBL7493657 0.97 SIGMAR1 (0.64) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL57393 0.97 SIGMAR1 (0.64) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL2571645 0.97 SIGMAR1 (0.64) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL27677126 0.94 SIGMAR1 (0.61) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL31498540 0.94 SIGMAR1 (0.61) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL1894392 0.94 SIGMAR1 (0.61) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL31284788 0.94 SIGMAR1 (0.61) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL363626 0.94 TAAR1 (0.61) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL11468970 0.94 TAAR1 (0.61) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3
Isobutylbenzene SCHEMBL113603 0.92 TAAR1 (0.58) SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040034258-A1 Crystalline MWW-type titanosilicate catalyst for producing oxidized compound, production process for the catalyst, and process for producing oxidized compound by using the catalyst SHOWA DENKO K.K. 2004-02-19 US claimed
EP-1324948-A2 CRYSTALLINE MWW-TYPE TITANOSILICATE, ITS PREPARATION AND USE THEREOF FOR PRODUCING EPOXIDES Showa Denko K.K. (JP) 2003-07-09 EP claimed
US-20030040649-A1 Crystalline mww-type titanosilicate catalyst for producing oxidized compound, production process for the catalyst, and process for producing oxidized compound by using the catalyst SHOWA DENKO K.K. (JP) 2003-02-27 US claimed
WO-2002028774-A2 CRYSTALLINE MWW-TYPE TITANOSILICATE , ITS PREPARATION AND USE THEREOF FOR PRODUCING EPOXIDES SHOWA DENKO K. K. (JP) 2002-04-11 WO claimed
JP-51143647-A None JP disclosed
CN-104704115-B With the active polypeptide of peroxygenases 诺维信公司 2018-11-02 CN disclosed
CN-104718286-B With the active polypeptide of peroxygenases 诺维信公司 2018-10-30 CN disclosed
CN-104704116-B Polypeptides having peroxygenase activity 诺维信公司 2018-09-28 CN disclosed
CN-104718287-B Polypeptide with peroxygenases activity 诺维信公司 2018-02-06 CN disclosed
CN-103635231-A Topical compositions DOW CORNING FRANCE SAS 2014-03-12 CN disclosed
CN-103547316-A Personal care and health care compositions DOW CORNING 2014-01-29 CN disclosed
JP-S51143647-A PROCESS FOR OBTAINING OPTICALLY ACTIVE TRANS-2,2-DIMETHYL-3-(2,2-DICHL OROVINYL) CYCLOPROPANECARBOXYLIC ACID SUMITOMO CHEM CO LTD 1976-12-10 JP disclosed