Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | HRAS | P01112 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892569 | 1.00 | MAOB (0.49) | MAOBLPAR3MMP13ADAMTS4PARP10 | |
| SCHEMBL6892246 | 0.89 | MAOB (0.44) | MAOBMMP13OPRK1PTPN1ITGB3 | |
| SCHEMBL6888131 | 0.84 | REN (0.46) | MMP13OPRK1REN | |
| SCHEMBL6888134 | 0.84 | REN (0.46) | MMP13OPRK1REN | |
| SCHEMBL6887237 | 0.78 | HRAS (0.51) | MAOBITGB3ITGA2BHRAS | |
| SCHEMBL6890928 | 0.77 | PSMB1 (0.49) | MAOBMMP13RENBCL2 | |
| SCHEMBL6890932 | 0.77 | PSMB1 (0.49) | MAOBMMP13RENBCL2 | |
| SCHEMBL6890435 | 0.76 | HRAS (0.46) | MAOBITGB3ITGA2BHRAS | |
| SCHEMBL6890591 | 0.75 | EPOR (0.52) | MAOBSMN1; SMN2ITGB3ITGA2BREN | |
| SCHEMBL6889863 | 0.75 | AAK1 (0.53) | MMP13REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737410-B1 | SMOOTH MUSCLE ANTIPROLIFERATION AGENTS; SUCH AS 1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-METHYL-CARBAMOYL)-2 -(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-6265382-B1 | E.G., (S--(R*, R*))-(1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-M ETHYL-CARBAM OYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-07-24 | — | — | US | disclosed |