Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690879 | 0.94 | DRD2 (0.47) | DRD2TBXA2RALOX5SLC6A4SLC6A3 | |
| SCHEMBL6898378 | 0.93 | ACMSD (0.39) | MAPTMAPK8ALDH1A1GAAPKM | |
| SCHEMBL6894303 | 0.93 | DRD2 (0.44) | DRD2TBXA2RSLC6A4SLC6A3MAPT | |
| SCHEMBL6895138 | 0.91 | HSP90AA1 (0.43) | DRD2TBXA2RALOX5SLC6A4SLC6A3 | |
| SCHEMBL6897038 | 0.91 | PLA2G2A (0.46) | DRD2TBXA2RSLC6A4SLC6A3MAPT | |
| SCHEMBL6895281 | 0.89 | FAAH (0.44) | DRD2TBXA2RSLC6A4SLC6A3MAPT | |
| SCHEMBL6890338 | 0.89 | MAPT (0.44) | DRD2TBXA2RSLC6A4SLC6A3MAPT | |
| SCHEMBL6893709 | 0.89 | MAPT (0.47) | MAPTPOLBALDH1A1GAAPKM | |
| SCHEMBL6694644 | 0.88 | AR (0.45) | MAPTMAPK8ALDH1A1GAAPKM | |
| SCHEMBL6897098 | 0.88 | CYP19A1 (0.44) | DRD2TBXA2RSLC6A4SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |