Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777740 | 0.90 | LMNA (0.46) | MAPTLMNAKDM4ESMN1; SMN2FAAH | |
| SCHEMBL6777299 | 0.90 | ALDH1A1 (0.43) | MAPTLMNAKDM4ESMN1; SMN2GAA | |
| SCHEMBL6779541 | 0.89 | TUBB4A (0.45) | MAPTLMNAALDH1A1CCR3 | |
| SCHEMBL6773282 | 0.88 | P2RY12 (0.43) | SMN1; SMN2CCR2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL6779180 | 0.84 | KDM4E (0.40) | MAPTKDM4ESMN1; SMN2GAAFAAH | |
| SCHEMBL6773021 | 0.82 | CCR3 (0.41) | MAPTKDM4ESMN1; SMN2HSD17B10TP53 | |
| SCHEMBL6777973 | 0.82 | TLR7 (0.37) | LMNASMN1; SMN2TLR7TLR8NUDT1 | |
| SCHEMBL6777443 | 0.81 | ALDH1A1 (0.40) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL6778341 | 0.81 | TLR7 (0.35) | TLR7TLR8NUDT1 | |
| SCHEMBL6772831 | 0.81 | FAAH (0.38) | FAAHALDH1A1TLR7TLR8NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720334-B2 | IMMUNE RESPONSE MODIFIERS; CYTOKINE BIOSYNTHESIS; VIRAL AND NEOPLASTIC DISEASES; 1-(4-(4-AMINO-6,7-DIMETHYL-1H-IMIDAZO (4,5-C)PYRIDIN-1-YL)BUTYL)-3-PHENYLUREA. | 3M INNOVATIVE PROPERTIES COMPANY | 2004-04-13 | — | — | US | claimed |