Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315672 | 0.86 | ADRB1 (0.52) | HTR6ADRB1HSD17B10USP2CYP1A2 | |
| SCHEMBL7476206 | 0.83 | ADRB1 (0.51) | HTR6ALDH1A1ADRB1HSD17B10ALOX15 | |
| SCHEMBL4006296 | 0.83 | HTR6 (0.39) | HTR6MAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27507890 | 0.82 | ADRB1 (0.48) | HTR6KDM4EALDH1A1GAAADRB1 | |
| SCHEMBL4313494 | 0.82 | CHRNB2 (0.41) | HTR6ADRB1HSD17B10USP2CYP1A2 | |
| SCHEMBL7601597 | 0.81 | ADRB1 (0.47) | HTR6ALDH1A1ADRB1HSD17B10USP2 | |
| SCHEMBL4317285 | 0.80 | ADORA2A (0.40) | ALDH1A1HSD17B10SRCKMT2A | |
| SCHEMBL4013116 | 0.80 | VSIR (0.38) | HTR6MAOBROCK2TLR7CYP3A4 | |
| SCHEMBL4324680 | 0.80 | HTR6 (0.39) | HTR6KDM4EALDH1A1ROCK2 | |
| SCHEMBL2640084 | 0.80 | CHRNB2 (0.49) | HTR6ADRB1HSD17B10USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756377-B2 | PIPERAZINYL)-3-(2-(3-(4-MORPHOLINYLMETHYL)PHENOXY)ETHOXY) PYRAZINE DERIVATIVES; FOR PROPHYLAXIS OR TREATMENT OF SEROTONIN-RELATED DISEASES | BIOVITRUM AB (SE) | 2004-06-29 | — | — | US | disclosed |
| EP-1337518-A1 | PIPERAZINYLPYRAZINES COMPOUNDS AS ANTAGONISTS OF SEROTONIN 5-HT2 RECEPTOR | BIOVITRUM AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-20020103204-A1 | Novel compounds and their use | PROXIMAGEN NEUROSCIENCE PLC (GB) | 2002-08-01 | — | — | US | disclosed |
| WO-2002040457-A1 | PIPERAZINYLPYRAZINES COMPOUNDS AS ANTAGONISTS OF SEROTONIN 5-HT2 RECEPTOR | BIOVITRUM AB (SE) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103204-A1 | Novel compounds and their use | HTR2C, HTR1A, HTR1B | HTR6 16/4885MAOB 123/4885F2 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.