Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 7/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894773 | 0.94 | FAAH (0.43) | FAAHCCR8MAPT | |
| SCHEMBL6690879 | 0.93 | DRD2 (0.47) | DRD2TBXA2RPPARGMAPTSLC6A4 | |
| SCHEMBL6894303 | 0.91 | DRD2 (0.44) | DRD2TBXA2RPPARGMAPTSLC6A4 | |
| SCHEMBL6774857 | 0.89 | FAAH (0.43) | FAAHP2RX3CCR8KCNH2CCR2 | |
| SCHEMBL6892182 | 0.89 | DRD2 (0.43) | DRD2TBXA2RPPARGMAPTSLC6A4 | |
| SCHEMBL6897038 | 0.89 | PLA2G2A (0.46) | DRD2TBXA2RCCR2MAPTSLC6A4 | |
| SCHEMBL6893122 | 0.88 | CCR8 (0.40) | P2RX3DRD2TBXA2RCCR8KCNH2 | |
| SCHEMBL6891577 | 0.88 | DRD2 (0.47) | DRD2TBXA2RCCR2PPARGSLC6A4 | |
| SCHEMBL6890338 | 0.87 | MAPT (0.44) | DRD2TBXA2RMAPTSLC6A4SLC6A3 | |
| SCHEMBL6896777 | 0.87 | FAAH (0.44) | FAAHCCR8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |