Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BBOX1 | O75936 | 1/20 | 0.52 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.52 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | CES1 | P23141 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1165959 | 0.78 | BBOX1 (0.50) | BBOX1EHMT2EHMT1TSHRF2 | |
| Benzene SCHEMBL28248657 | 0.73 | BBOX1 (0.46) | BBOX1EHMT2EHMT1TSHRF2 | |
| Benzene Selenoic Acid SCHEMBL11047165 | 0.73 | BBOX1 (0.73) | BBOX1EHMT2EHMT1F2LMNA | |
| Benzene Selenoic Acid SCHEMBL1440596 | 0.69 | — | — | |
| SCHEMBL28188957 | 0.69 | BBOX1 (0.41) | BBOX1EHMT2EHMT1TSHRALDH1A1 | |
| SCHEMBL158572 | 0.67 | BBOX1 (0.58) | BBOX1EHMT2EHMT1TSHRTDP1 | |
| SCHEMBL7379226 | 0.67 | — | — | |
| Benzene Selenoic Acid SCHEMBL27636752 | 0.67 | BBOX1 (0.94) | BBOX1EHMT2EHMT1TSHRCYP3A4 | |
| Benzene Selenoic Acid SCHEMBL28844455 | 0.67 | BBOX1 (0.94) | BBOX1EHMT2EHMT1TSHRCYP3A4 | |
| Benzene Selenoic Acid SCHEMBL8752795 | 0.67 | BBOX1 (0.94) | BBOX1EHMT2EHMT1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527573-B9 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2022-07-06 | — | — | EP | disclosed |
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | GILEAD SCIENCES, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| EP-3783001-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | Gilead Sciences, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| EP-3527573-B1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2020-08-12 | — | — | EP | disclosed |
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2020-07-16 | — | — | US | disclosed |
| EP-3527573-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | Gilead Sciences, Inc. (US) | 2019-08-21 | — | — | EP | disclosed |
| US-20180022757-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2018-01-25 | — | — | US | disclosed |
| EP-3157933-A2 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | Gilead Sciences, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| US-20150368264-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2015-12-24 | — | — | US | disclosed |
| WO-2015195656-A2 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES ,INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| US-6833468-B2 | Reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfluoroalkylaldehyde to obtain a condensate, hydrolyzing | CENTRAL GLASS COMPANY, LIMITED (JP) | 2004-12-21 | — | — | US | disclosed |
| US-6642409-B2 | Reacting an imine with a hemiacetal; hydrolysis under acid conditions | CENTRAL GLASS COMPANY, LIMITED (JP) | 2003-11-04 | — | — | US | disclosed |
| US-6639100-B2 | Baeyer-Villiger oxidation of an optically active 4,4,4-tri-fluoro-3-hydroxy-1-aryl-1-butanone; purification by precipitation and removing racemic crystals; agriculture; drugs; ferroelectric liquid crystals; chemical intermediates | CENTRAL GLASS COMPANY, LIMITED (JP) | 2003-10-28 | — | — | US | disclosed |
| US-20030100767-A1 | Reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfluoroalkylaldehyde to obtain a condensate, hydrolyzing | CENTRAL GLASS COMPANY, LIMITED | 2003-05-29 | — | — | US | disclosed |
| US-20030088095-A1 | Reacting an optically active imine with a hemiacetal of a perfluoroalkylaldehyde or a hydrate; hydrolyzing the condensate under an acid condition. | CENTRAL GLASS COMPANY, LIMITED | 2003-05-08 | — | — | US | disclosed |
| US-20020016511-A1 | Reacting an imine with a hemiacetal; hydrolysis under acid conditions | CENTRAL GLASS COMPANY, LIMITED (JP) | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368264-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | BBOX1 1218/4885EHMT2 2790/4885EHMT1 3102/4885 |
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | BBOX1 1218/4885EHMT2 2790/4885EHMT1 3102/4885 |
| US-20180022757-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | BBOX1 1218/4885EHMT2 2790/4885EHMT1 3102/4885 |
| US-20030100767-A1 | Reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfluoroalkylaldehyde to obtain a condensate, hydrolyzing | ADH1C, ADH1A, HPD | BBOX1 72/4885EHMT2 3401/4885EHMT1 2780/4885 |
| US-20030088095-A1 | Reacting an optically active imine with a hemiacetal of a perfluoroalkylaldehyde or a hydrate; hydrolyzing the condensate under an acid condition. | ADH1C, ADH1A, HPD | BBOX1 57/4885EHMT2 3102/4885EHMT1 2624/4885 |
| US-20020016511-A1 | Reacting an imine with a hemiacetal; hydrolysis under acid conditions | ADH1C, ADH1A, HPD | BBOX1 41/4885EHMT2 2902/4885EHMT1 2653/4885 |
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | CPS1, SDHA, DHPS | BBOX1 1218/4885EHMT2 2790/4885EHMT1 3102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.