Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133846 | 0.97 | KMT2A (0.54) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| SCHEMBL1249882 | 0.97 | KMT2A (0.54) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| SCHEMBL5706178 | 0.97 | KMT2A (0.54) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| SCHEMBL3192403 | 0.97 | KMT2A (0.54) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| SCHEMBL9780310 | 0.97 | KMT2A (0.54) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| SCHEMBL3063106 | 0.97 | KMT2A (0.54) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| SCHEMBL6325898 | 0.97 | KMT2A (0.54) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| SCHEMBL7191365 | 0.95 | KMT2A (0.52) | KMT2ASMN1; SMN2CA2NPC1RAB9A | |
| Potassium Ion SCHEMBL10497572 | 0.92 | KMT2A (0.48) | KMT2ASMN1; SMN2 | |
| SCHEMBL31314548 | 0.90 | KMT2A (0.48) | KMT2ASMN1; SMN2CA2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208076-B1 | PROCESS FOR THE PREPARATION OF ALKANOYLOXY-BENZENESULFONIC ACIDS AND SALTS THEREOF | EASTMAN CHEM CO (US) | 2004-02-18 | — | — | EP | disclosed |
| EP-1208076-A1 | PROCESS FOR THE PREPARATION OF ALKANOYLOXY-BENZENESULFONIC ACIDS AND SALTS THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2002-05-29 | — | — | EP | disclosed |
| US-6218555-B1 | REACTING PHENOL WITH AN ALKANOIC ACID IN THE PRESENCE OF TRIFLUOROACETIC ACID AND TRIFLUOROACETIC ANHYDRIDE TO PRODUCE A ARYL ALKANOATE ESTER AND CONTACTING THE REACTION MIXTURE WITH A SULFONATING AGENT | EASTMAN CHEMICAL COMPANY | 2001-04-17 | — | — | US | disclosed |
| WO-2001017940-A1 | PROCESS FOR THE PREPARATION OF ALKANOYLOXY-BENZENESULFONIC ACIDS AND SALTS THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |