Sugi Predict

Sugi Predict / Compounds / SCHEMBL6904240

SCHEMBL6904240

SCHEMBL6904240

O=Cc1cc(Cl)c(F)c(Cl)c1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.52
▸ HSD17B10 Q99714 1/20 0.40
▸ ALDH1A3 P47895 3/20 0.39
▸ VCAM1 P19320 1/20 0.36
▸ ALDH3A1 P30838 2/20 0.36
▸ TDP1 Q9NUW8 2/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ ERN1 O75460 2/20 0.32
▸ CYP2A6 P11509 1/20 0.32
▸ TYR P14679 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ PTGS2 P35354 1/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ TTR P02766 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19136810 0.88 ALDH1A1 (0.46) ALDH1A1HSD17B10ALDH1A3VCAM1ALDH3A1
SCHEMBL29686950 0.84 ALDH1A1 (0.43) ALDH1A1HSD17B10ALDH1A3VCAM1ALDH3A1
SCHEMBL27702448 0.81 ALDH1A1 (0.45) ALDH1A1HSD17B10ALDH1A3VCAM1ALDH3A1
SCHEMBL9340546 0.81 KIF11 (0.42) ALDH1A1HSD17B10ALDH1A3VCAM1ALDH3A1
SCHEMBL31454771 0.80 ALDH1A1 (0.48) ALDH1A1HSD17B10ALDH1A3VCAM1ALDH3A1
SCHEMBL16149314 0.80 ALDH1A1 (0.48) ALDH1A1HSD17B10ALDH1A3VCAM1ALDH3A1
SCHEMBL27204190 0.80 ALDH1A1 (0.39) ALDH1A1HSD17B10ALDH1A3ALDH3A1L3MBTL1
SCHEMBL31357006 0.78 VCAM1 (0.59) ALDH1A1ALDH1A3VCAM1ALDH3A1TDP1
SCHEMBL1312098 0.78 ALDH1A1 (0.56) ALDH1A1HSD17B10ALDH1A3VCAM1ALDH3A1
SCHEMBL21675992 0.77 ALDH1A1 (0.41) ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1390336-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2004-02-25 — — EP claimed
WO-2002096849-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2002-12-05 — — WO claimed
EP-4709712-A1 GSK3A INHIBITORS AND METHODS OF USE THEREOF Blueprint Medicines Corporation (US) 2026-03-18 — — EP disclosed
US-12187709-B2 Lactams as CBL-B inhibitors selective over C-CBL GENENTECH, INC. (US) 2025-01-07 — — US disclosed
WO-2024233900-A1 GSK3A INHIBITORS AND METHODS OF USE THEREOF BLUEPRINT MEDICINES CORPORATION (US) 2024-11-14 — — WO disclosed
EP-4426691-A1 LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL Genentech, Inc. (US) 2024-09-11 — — EP disclosed
CN-118201921-A Lactams as CBL-B inhibitors selective for C-CBL 基因泰克公司 2024-06-14 — — CN disclosed
CN-114539249-B Podophyllotoxin derivative tubulin inhibitor, and preparation method and medical application thereof 中国药科大学 2024-01-26 — — CN disclosed
CN-112272670-B Di-ring derivative-containing inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2023-12-12 — — CN disclosed
US-20230212153-A1 LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL GENENTECH, INC. (US) 2023-07-06 — — US disclosed
WO-2023081853-A1 LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL GENENTECH, INC. (US) 2023-05-11 — — WO disclosed
US-10570129-B2 Carboline antiparasitics ZOETIS SERVICES LLC (US) 2020-02-25 — — US disclosed
US-20200031822-A1 CARBOLINE ANTIPARASITICS ZOETIS SERVICES LLC (US) 2020-01-30 — — US disclosed
EP-3313837-A1 CARBOLINE ANTIPARASITICS Zoetis Services LLC (US) 2018-05-02 — — EP disclosed
US-20180111896-A1 INHIBITORS AND THEIR USES MEDICAL RESEARCH COUNCIL (GB) 2018-04-26 — — US disclosed
WO-2016209635-A1 CARBOLINE ANTIPARASITICS ZOETIS SERVICES LLC (US) 2016-12-29 — — WO disclosed
WO-2016162689-A1 INHIBITORS AND THEIR USES MEDICAL RESEARCH COUNCIL (GB) 2016-10-13 — — WO disclosed
EP-1390336-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2004-02-25 — — EP disclosed
WO-2002096849-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2002-12-05 — — WO disclosed
EP-1101752-A2 Process for the preparation of halogenated benzyl alcohols Clariant GmbH (DE) 2001-05-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180111896-A1 INHIBITORS AND THEIR USES PPP1R1B, PPP5C, PPP1R15A ALDH1A1 2580/4885HSD17B10 3839/4885ALDH1A3 3873/4885
US-20230212153-A1 LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL CBL, CBLB, CBLC ALDH1A1 3554/4885HSD17B10 3331/4885ALDH1A3 4504/4885
US-12187709-B2 Lactams as CBL-B inhibitors selective over C-CBL CBL, CBLB, CBLC ALDH1A1 3554/4885HSD17B10 3331/4885ALDH1A3 4504/4885
US-10570129-B2 Carboline antiparasitics ADRA1D, DRD1, CHRM1 ALDH1A1 381/4885HSD17B10 2725/4885ALDH1A3 1517/4885
US-20200031822-A1 CARBOLINE ANTIPARASITICS DRD1, ADRA1D, DRD2 ALDH1A1 334/4885HSD17B10 2349/4885ALDH1A3 1559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.