Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6906108 | 0.89 | MAPT (0.48) | MAPTDAOLMNAGSK3BNOTUM | |
| SCHEMBL6903690 | 0.83 | MAPT (0.45) | MAPTDAOLMNAGSK3BNOTUM | |
| SCHEMBL6909011 | 0.78 | GSK3B (0.56) | MAPTKDM4ELMNACYP1A2GSK3B | |
| SCHEMBL5215641 | 0.69 | MAPK14 (0.71) | GSK3BMAPK14 | |
| SCHEMBL16127491 | 0.67 | IKBKB (0.53) | MAPTNOTUMIKBKBCNR2 | |
| SCHEMBL11178917 | 0.67 | NPC1 (0.44) | MAPTKDM4ELMNACYP1A2CYP3A4 | |
| SCHEMBL3265916 | 0.67 | MAPK14 (0.53) | MAPTKDM4ELMNAHTTGSK3B | |
| SCHEMBL13290027 | 0.66 | MAPT (0.59) | MAPTNOTUMIKBKBPGRXDH | |
| SCHEMBL3561082 | 0.66 | MAPT (0.48) | MAPTDAOKDM4ELMNACYP1A2 | |
| SCHEMBL29678302 | 0.66 | TSHR (0.58) | NOTUMPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673923-B2 | PYRAZOLE AND PYRAZOLONE DERIVATIVES, USEFUL AS RNA POLYMERASE INHIBITORS AND ANTIBIOTICS | TULARIK INC. | 2004-01-06 | — | — | US | disclosed |
| US-20020049205-A1 | Pyrazole antimicrobial agents | AMGEN INC. | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049205-A1 | Pyrazole antimicrobial agents | POLRMT, POLR1C, RNGTT | MAPT 3935/4885DAO 1742/4885KDM4E 2079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.