Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265916 | 0.89 | MAPK14 (0.53) | GSK3BGAAMAPK14SERPINE1POLB | |
| SCHEMBL5215641 | 0.83 | MAPK14 (0.71) | GSK3BMAPK14 | |
| SCHEMBL3561082 | 0.80 | MAPT (0.48) | GAACYP1A2SERPINE1POLBHPGD | |
| SCHEMBL1573566 | 0.79 | TYMP (0.62) | GSK3BGAACYP1A2SERPINE1HPGD | |
| SCHEMBL1573392 | 0.79 | TYMP (0.62) | GSK3BGAACYP1A2SERPINE1HPGD | |
| SCHEMBL6906868 | 0.78 | MAPT (0.50) | GSK3BGAAMAPK14CYP1A2LMNA | |
| SCHEMBL7093919 | 0.77 | ALDH1A1 (0.55) | GSK3BGAACYP1A2SERPINE1HPGD | |
| SCHEMBL7092828 | 0.77 | ALDH1A1 (0.55) | GSK3BGAACYP1A2SERPINE1HPGD | |
| SCHEMBL4842006 | 0.70 | TYMP (0.51) | GAASERPINE1HPGDTYMPKDM4E | |
| SCHEMBL3555150 | 0.70 | GCGR (0.58) | GSK3BGAAMAPK14LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673923-B2 | PYRAZOLE AND PYRAZOLONE DERIVATIVES, USEFUL AS RNA POLYMERASE INHIBITORS AND ANTIBIOTICS | TULARIK INC. | 2004-01-06 | — | — | US | disclosed |
| US-20020049205-A1 | Pyrazole antimicrobial agents | AMGEN INC. | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049205-A1 | Pyrazole antimicrobial agents | POLRMT, POLR1C, RNGTT | GSK3B 3342/4885GAA 1642/4885MAPK14 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.