Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPEPPS | P55786 | 11/20 | 0.39 |
| ▸ | ANPEP | P15144 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833723 | 0.87 | ADORA3 (0.37) | LMNA | |
| SCHEMBL6386486 | 0.86 | PDE4A (0.37) | LMNA | |
| SCHEMBL30544925 | 0.86 | ADORA2A (0.49) | LMNAHIF1A | |
| SCHEMBL4834707 | 0.86 | PDE4A (0.37) | LMNA | |
| SCHEMBL4948918 | 0.77 | LMNA (0.43) | TP53LMNA | |
| SCHEMBL29606234 | 0.76 | PRKAB2 (0.52) | SMN1; SMN2LMNACYP1A2MAPK1HTT | |
| SCHEMBL5498228 | 0.76 | LMNA (0.37) | TP53LMNA | |
| SCHEMBL5492971 | 0.76 | NT5E (0.38) | TP53LMNA | |
| SCHEMBL5735963 | 0.75 | LMNA (0.35) | TP53LMNA | |
| SCHEMBL9404373 | 0.75 | LMNA (0.35) | TP53LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699690-B2 | LINKED AND CONTROLLING THE EXPRESSION OF A HETEROLOGOUS ENZYME, FOR EXAMPLE VARICELLA ZOSTER VIRUS THYMIDINE KINASE OR NON-MAMMALIAM CYTOSINE DEAMINASE | SMITHKLINE BEECHAM CORPORATION | 2004-03-02 | — | — | US | disclosed |
| US-20020055482-A1 | Linked and controlling the expression of a heterologous enzyme, for example Varicella Zoster Virus Thymidine Kinase or non-mammaliam Cytosine Deaminase | SMITHKLINE BEECHAM CORPORATION | 2002-05-09 | — | — | US | disclosed |
| US-6300490-B1 | EXPRESSION VECTOR CODING CYTOSINE DEAMINASE; FOR USE IN THE TREATMENT OF CANCERS | GLAXO WELLCOME INC. | 2001-10-09 | — | — | US | disclosed |
| EP-0294114-A2 | Antiviral compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055482-A1 | Linked and controlling the expression of a heterologous enzyme, for example Varicella Zoster Virus Thymidine Kinase or non-mammaliam Cytosine Deaminase | TK1, CDA, DCTD | NPEPPS 1063/4885ANPEP 2720/4885SMN1; SMN2 2729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.