SCHEMBL4833723

SCHEMBL4833723

CC(=O)C(O)[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@@](O)(C(C)=O)[C@@]1(O)C(C)=O

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 11/20 0.37
ADORA2A P29274 7/20 0.37
ADORA1 P30542 6/20 0.34
ADORA2B P29275 4/20 0.34
AHCY P23526 2/20 0.34
TSHR P16473 1/20 0.34
LMNA P02545 1/20 0.34
THRB P10828 1/20 0.34
BLM P54132 1/20 0.34
KMT2A Q03164 1/20 0.34
HSP90AA1 P07900 1/20 0.34
HSP90B1 P14625 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6386486 0.88 PDE4A (0.37) ADORA3ADORA2AADORA1ADORA2BAHCY
SCHEMBL4834707 0.88 PDE4A (0.37) ADORA3ADORA2AADORA1ADORA2BAHCY
SCHEMBL30544925 0.88 ADORA2A (0.49) ADORA3ADORA2AADORA1ADORA2BAHCY
SCHEMBL6909391 0.87 NPEPPS (0.39) LMNA
SCHEMBL10930706 0.82 ACHE (0.38) ADORA2A
SCHEMBL5498228 0.81 LMNA (0.37) ADORA3ADORA2AADORA1ADORA2BLMNA
SCHEMBL29606234 0.80 PRKAB2 (0.52) ADORA3ADORA2AADORA1TSHRLMNA
SCHEMBL4948918 0.79 LMNA (0.43) ADORA3ADORA2AADORA1ADORA2BLMNA
SCHEMBL9122994 0.78 ADORA3 (0.37) ADORA3ADORA2AADORA1ADORA2BAHCY
SCHEMBL9122999 0.78 ADORA3 (0.37) ADORA3ADORA2AADORA1ADORA2BAHCY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113173961-B Method for preparing adenosine 远大生命科学(辽宁)有限公司 2023-06-30 CN disclosed
WO-2022048680-A1 METHOD FOR PREPARING AND PURIFYING ADENOSINE 远大生命科学(辽宁)有限公司 2022-03-10 WO disclosed
EP-2707483-B1 METHODS AND MATERIALS FOR NUCLEIC ACID MANIPULATION RWTH AACHEN UNIV (DE) 2017-10-18 EP disclosed
US-20120295311-A1 Methods and Materials for Nucleic Acid Manipulation BASF SE (DE) 2012-11-22 US disclosed
CN-102675391-A Technique for synthesizing adenosin by chemical method SHANDONG KAISHENG NEW MATERIALS CO LTD 2012-09-19 CN disclosed
US-7345164-B2 Production method of 5′-acyloxynucleoside compound AJINOMOTO CO., INC. (JP) 2008-03-18 US disclosed
US-20060014944-A1 Processes for production of nucleosides AJINOMOTO CO., INC. (JP) 2006-01-19 US disclosed
EP-1589027-A1 PROCESSES FOR PRODUCTION OF NUCLEOSIDES Ajinomoto Co., Inc. (JP) 2005-10-26 EP disclosed
US-20040230053-A1 Production method of 5'-acyloxynucleoside compound AJINOMOTO CO., INC. (JP) 2004-11-18 US disclosed
EP-1471071-A1 Production method of 5'-acyloxynucleoside compound Ajinmoto Co., Inc. (JP) 2004-10-27 EP disclosed
EP-0759925-A1 ADENOSINE DERIVATIVES SANDOZ LTD. (CH) 1997-03-05 EP disclosed
US-5596094-A Process for preparing 2' -0- alkyl adenosine derivatives SANDOZ LTD. (CH) 1997-01-21 US disclosed
WO-1995030683-A1 ADENOSINE DERIVATIVES SANDOZ LTD. (CH) 1995-11-16 WO disclosed
US-5466793-A Catalytic reducing of a nucleoside with hydrogen in the presence of palladium and recovering AJINOMOTO CO., INC. (JP) 1995-11-14 US disclosed
US-5290927-A Process for preparing 2',3'-dideoxyadenosine AJINOMOTO CO., INC. (JP) 1994-03-01 US disclosed
WO-1990008147-A1 PURINE NUCLEOSIDES, PROCESS FOR PRODUCING THEM, AND DRUGS CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1990-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060014944-A1 Processes for production of nucleosides NUDT1, NT5C3B, DNTT ADORA3 445/4885ADORA2A 263/4885ADORA1 251/4885
US-20040230053-A1 Production method of 5'-acyloxynucleoside compound ALKBH2, DUT, ALKBH1 ADORA3 1219/4885ADORA2A 1486/4885ADORA1 1406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.