Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 1/20 | 0.43 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303657 | 0.91 | PKM (0.44) | CLPPALDH1A1NPSR1MAPTMAPK1 | |
| SCHEMBL2301004 | 0.88 | SMN1; SMN2 (0.43) | CLPPALDH1A1NPSR1MAPTMAPK1 | |
| SCHEMBL2303047 | 0.88 | ALDH1A1 (0.47) | CLPPALDH1A1KMT2A | |
| SCHEMBL2309384 | 0.87 | SMN1; SMN2 (0.41) | CLPPALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2302430 | 0.86 | MAPT (0.41) | CLPPALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL2347857 | 0.83 | PKM (0.44) | CLPPALDH1A1NPSR1MAPTMAPK1 | |
| SCHEMBL2300504 | 0.82 | UBE2M (0.41) | CLPPBRS3ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6909368 | 0.79 | DRD2 (0.45) | CLPPBRS3ALDH1A1MAPTKMT2A | |
| SCHEMBL2348266 | 0.79 | ALDH1A1 (0.45) | CLPPBRS3ALDH1A1NPSR1MAPT | |
| SCHEMBL6909376 | 0.78 | KMT2A (0.51) | CLPPALDH1A1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101804-A1 | PYRAZOLO PIPERIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-08-25 | — | — | WO | disclosed |