Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.41 |
| ▸ | PI4KA | P42356 | 12/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 12/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 12/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | AHCY | P23526 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558880 | 0.86 | PI4KA (0.44) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL580610 | 0.76 | ADORA2A (0.64) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28413958 | 0.74 | ADORA2A (0.62) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL1065184 | 0.74 | ADORA2A (0.44) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL3474052 | 0.74 | ADORA2A (0.44) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28410735 | 0.73 | ADORA2A (0.60) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28891447 | 0.73 | ADORA2A (0.40) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL1831279 | 0.71 | XDH (0.50) | — | |
| SCHEMBL27773184 | 0.70 | ADORA2A (0.43) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL27879438 | 0.69 | CDK1 (0.41) | AHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040049022-A1 | Composition & methods for treatment and screening | NYCE JONATHAN W (US) | 2004-03-11 | — | — | US | claimed |
| WO-2004011613-A2 | COMPOSITION & METHODS FOR TREATMENT AND SCREENING | EPIGENESIS PHARMACEUTICALS, INC. (US) | 2004-02-05 | — | — | WO | claimed |
| EP-2699271-A2 | METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING COMPONENTS THAT SELF ASSEMBLE IN CELLS AND PRODUCE RNAI ACTIVITY | Smith Holdings, LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012145729-A2 | METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING COMPONENTS THAT SELF ASSEMBLE IN CELLS AND PRODUCE RNAI ACTIVITY | SMITH HOLDINGS, LLC (US) | 2012-10-26 | — | — | WO | disclosed |