Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.34 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528056 | 0.89 | DNM1 (0.35) | FDPS | |
| SCHEMBL9278253 | 0.83 | OPRM1 (0.37) | FDPSGPR84 | |
| SCHEMBL22634846 | 0.81 | FDPS (0.39) | FDPSGPR84 | |
| SCHEMBL11223579 | 0.81 | FDPS (0.39) | FDPSGPR84 | |
| SCHEMBL8944193 | 0.81 | FDPS (0.39) | FDPSGPR84 | |
| SCHEMBL25416009 | 0.81 | FDPS (0.39) | FDPSGPR84 | |
| SCHEMBL3369505 | 0.78 | CA2 (0.42) | CA2MAPK1FDPSGPR84CA1 | |
| SCHEMBL16970392 | 0.77 | FDPS (0.34) | CA2MAPK1FDPSCA1 | |
| SCHEMBL6567438 | 0.77 | FDPS (0.32) | FDPS | |
| SCHEMBL8679092 | 0.76 | GPR84 (0.44) | CA2GPR84FFAR1MAPTLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256509-B1 | TWO COMPONENT COATING COMPOSITIONS AND COATINGS PRODUCED FROM THE SAME FOR IMPROVED EROSION RESISTANCE | AKZO NOBEL COATINGS INT BV (NL) | 2019-04-24 | — | — | EP | disclosed |
| EP-2421925-B1 | MULTILAYER COATING, PRODUCTION AND USE THEREOF FOR THE ADHESION OF GLASS PANES | BASF COATINGS GMBH (DE) | 2018-04-18 | — | — | EP | disclosed |
| EP-3049487-B1 | MULTISTAGE COATING METHOD AND LOW TEMPERATURE CURABLE COATINGS MADE THEREFROM AND THEIR USE | BASF COATINGS GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |
| EP-3256509-A1 | TWO-COMPONENT COATING COMPOSITIONS AND COATINGS MADE THEREFROM FOR INCREASING RESISTANCE AGAINST EROSION | BASF Coatings GmbH (DE) | 2017-12-20 | — | — | EP | disclosed |
| EP-3010984-B1 | PIGMENTED COATING AGENT AND METHOD FOR PRODUCING A MULTILAYER COATING USING THE PIGMENTED COATING AGENT FOR PRODUCING A PANE ADHESION | BASF COATINGS GMBH (DE) | 2017-03-29 | — | — | EP | disclosed |
| EP-2782966-B1 | SOLVENTBORNE CLEARCOAT COATING COMPOSITION, PROCESS FOR PRODUCING IT AND USE THEREOF | BASF COATINGS GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |
| EP-2809736-B1 | CLEARCOAT COMPOSITION, METHOD FOR PRODUCTION AND USE | BASF COATINGS GMBH (DE) | 2016-08-24 | — | — | EP | disclosed |
| EP-3058039-A1 | AQUEOUS COATING COMPOSITION AND PRODUCTION OF TOPCOAT LAYERS BY USING THE COATING COMPOSITION | BASF Coatings GmbH (DE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2016128166-A1 | TWO-COMPONENT COATING COMPOSITIONS AND COATINGS MADE THEREFROM FOR INCREASING RESISTANCE AGAINST EROSION | BASF COATINGS GMBH (DE) | 2016-08-18 | — | — | WO | disclosed |
| EP-2519593-B1 | ANHYDROUS COMPOSITION AS A COATING AGENT FOR FUNCTIONAL LAYERS OF A MULTILAYER PAINT | BASF COATINGS GMBH (DE) | 2016-04-27 | — | — | EP | disclosed |
| WO-1987005306-A1 | DISPERSIONS OF CROSS-LINKED POLYMER MICRO-PARTICLES IN AQUEOUS MEDIA, PROCESS FOR PREPARING SUCH DISPERSIONS AND COATING COMPOSITIONS CONTAINING SUCH DISPERSIONS | BASF LACKE + FARBEN AKTIENGESELLSCHAFT (DE) | 1987-09-11 | — | — | WO | disclosed |
| EP-0234361-A1 | Aqueous dispersions of cross-linked polymer particles, process for the preparation of these dispersions and coating compositions containing these dispersions | BASF Lacke + Farben AG (DE) | 1987-09-02 | — | — | EP | disclosed |
| EP-0234362-A1 | Aqueous dispersions of cross-linked polymer particles, process for the preparation of these dispersions and coating compositions containing these dispersions | BASF Lacke + Farben AG (DE) | 1987-09-02 | — | — | EP | disclosed |
| EP-0089497-B1 | Process for multilayer coating, substrate thus coated and waterborne coating composition | BASF Lacke + Farben AG (DE) | 1987-04-29 | — | — | EP | disclosed |
| EP-0089488-B1 | WATER-DISPERSIBLE BINDERS FOR CATIONIC ELECTROCOATING VARNISHES, AND PROCESS FOR THEIR PREPARATION | BASF Lacke + Farben AG (DE) | 1986-06-25 | — | — | EP | disclosed |
| EP-0059895-B1 | WATER-DISPERSIBLE BINDERS FOR CATIONIC ELECTRODEPOSITION, AND A METHOD FOR THEIR PREPARATION | BASF Lacke + Farben AG (DE) | 1985-04-17 | — | — | EP | disclosed |
| EP-0089497-A2 | Process for multilayer coating, substrate thus coated and waterborne coating composition | BASF Lacke + Farben AG (DE) | 1983-09-28 | — | — | EP | disclosed |
| EP-0089488-A2 | Water-dispersible binders for cationic electrocoating varnishes, and process for their preparation | BASF Lacke + Farben AG (DE) | 1983-09-28 | — | — | EP | disclosed |
| WO-1982003082-A1 | WATER-DISPERSIBLE BINDER FOR CATIONIC ELECTROPHORETIC STEEPING L ACQUER AND METHOD FOR ITS PREPARATION | DIEFENBACH HORST | 1982-09-16 | — | — | WO | disclosed |
| EP-0059895-A1 | Water-dispersible binders for cationic electrodeposition, and a method for their preparation | BASF Lacke + Farben AG (DE) | 1982-09-15 | — | — | EP | disclosed |