Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 7/20 | 0.32 |
| ▸ | NPC1 | O15118 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820940 | 0.83 | SMN1; SMN2 (0.35) | HCAR2SMN1; SMN2TERTRAB9ANPC1 | |
| SCHEMBL2214214 | 0.79 | ALDH1A1 (0.43) | HCAR2MAPTALDH1A1LMNAHTT | |
| SCHEMBL6920029 | 0.75 | HCAR2 (0.39) | HCAR2SMN1; SMN2TERTRAB9ANPC1 | |
| SCHEMBL6920152 | 0.73 | SMN1; SMN2 (0.39) | HCAR2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL6919835 | 0.72 | L3MBTL1 (0.47) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL10753599 | 0.68 | RAB9A (0.44) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL6918282 | 0.68 | ALDH1A1 (0.42) | HCAR2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL6921028 | 0.68 | P2RX7 (0.38) | SMN1; SMN2TERTRAB9ANPC1MAPT | |
| SCHEMBL10962761 | 0.66 | SMN1; SMN2 (0.37) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL7441039 | 0.66 | HCAR2 (0.39) | HCAR2SMN1; SMN2RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |