Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558092 | 0.75 | LMNA (0.35) | LMNASMN1; SMN2POLBHTTALDH1A1 | |
| SCHEMBL12408237 | 0.74 | NPSR1 (0.43) | LMNASMN1; SMN2ALDH1A1NPSR1MAPT | |
| SCHEMBL9186739 | 0.72 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL11456944 | 0.72 | ABL1 (0.41) | SMN1; SMN2POLBALDH1A1GAA | |
| SCHEMBL9432033 | 0.72 | ROCK2 (0.33) | ALDH1A1ROCK2 | |
| SCHEMBL8716129 | 0.70 | ALDH1A1 (0.40) | LMNAHTTALDH1A1 | |
| SCHEMBL10804762 | 0.68 | SMN1; SMN2 (0.34) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL11623973 | 0.67 | — | — | |
| SCHEMBL22063690 | 0.67 | LMNA (0.47) | LMNAPOLBHTTALDH1A1NPSR1 | |
| SCHEMBL1361249 | 0.67 | MMP1 (0.38) | LMNASMN1; SMN2POLBHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024060-A2 | METALLOPROTEINASE INHIBITORS AND INTERMEDIATES FOR PREPARATION THEREOF | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |