Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589388 | 0.94 | KEAP1 (0.61) | KEAP1NFE2L2L3MBTL1SMN1; SMN2CHRM3 | |
| SCHEMBL10697753 | 0.79 | L3MBTL1 (0.43) | KEAP1NFE2L2L3MBTL1SMN1; SMN2CHRM3 | |
| SCHEMBL6925355 | 0.78 | LMNA (0.44) | L3MBTL1SMN1; SMN2CHRM3LMNACHRM2 | |
| SCHEMBL2764040 | 0.74 | KEAP1 (0.85) | KEAP1NFE2L2CHRM3LMNACHRM2 | |
| SCHEMBL17490358 | 0.74 | SMN1; SMN2 (0.53) | L3MBTL1SMN1; SMN2CHRM3LMNACHRM2 | |
| SCHEMBL10696448 | 0.73 | KEAP1 (0.44) | KEAP1NFE2L2L3MBTL1SMN1; SMN2CHRM3 | |
| SCHEMBL20412355 | 0.72 | SMN1; SMN2 (0.56) | L3MBTL1SMN1; SMN2LMNANAPRTP4HTM | |
| SCHEMBL10697581 | 0.72 | KEAP1 (0.43) | KEAP1NFE2L2L3MBTL1SMN1; SMN2CHRM3 | |
| SCHEMBL1827357 | 0.72 | L3MBTL1 (0.55) | L3MBTL1SMN1; SMN2LMNANAPRTP4HTM | |
| SCHEMBL16132353 | 0.71 | SMN1; SMN2 (0.50) | L3MBTL1SMN1; SMN2CHRM3CHRM2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515011-B2 | Anticoagulants | MERCK & CO., INC. | 2003-02-04 | — | — | US | disclosed |
| US-20020119992-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2002-08-29 | — | — | US | disclosed |
| WO-2002050056-A1 | BENZYLAMINE DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119992-A1 | Thrombin inhibitors | SERPINC1, F2, TFPI | KEAP1 1766/4885NFE2L2 2293/4885L3MBTL1 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.