Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693187 | 0.68 | RXRA (0.46) | ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL12033673 | 0.67 | — | — | |
| SCHEMBL692285 | 0.63 | FGFR1 (0.43) | ALDH1A1SMN1; SMN2TSHRDAO | |
| SCHEMBL9063070 | 0.62 | ALDH1A1 (0.36) | TPMTALDH1A1SMN1; SMN2TSHRDAO | |
| SCHEMBL69007 | 0.56 | TPMT (0.56) | TPMTALDH1A1SMN1; SMN2TSHRDAO | |
| SCHEMBL3392120 | 0.56 | TDP1 (0.48) | ALDH1A1SMN1; SMN2TSHRNOTUM | |
| SCHEMBL838160 | 0.52 | — | — | |
| SCHEMBL842692 | 0.50 | NOTUM (0.42) | TPMTALDH1A1SMN1; SMN2NOTUM | |
| SCHEMBL829193 | 0.50 | NOTUM (0.42) | TPMTALDH1A1SMN1; SMN2TSHRNOTUM | |
| SCHEMBL207579 | 0.50 | NOTUM (0.42) | TPMTALDH1A1SMN1; SMN2TSHRNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9060953-B2 | 1-hexyl-1H-pyrazole-4,5-diamine hemisulfate, and its use in dyeing compositions | THE PROCTER & GAMBLE COMPANY (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140289973-A1 | 1-Hexyl-1H-Pyrazole-4,5-Diamine Hemisulfate, and Its Use in Dyeing Compositions | WELLA OPERATIONS US, LLC | 2014-10-02 | — | — | US | disclosed |
| US-8784505-B2 | 1-hexzl-1H-pyrazole-4,5-diamine hemisulfate, and its use in dyeing compositions | THE PROCTER & GAMBLE COMPANY (US) | 2014-07-22 | — | — | US | disclosed |
| US-20130212810-A1 | 1-Hexzl-1H-Pyrazole-4,5-Diamine Hemisulfate, and Its Use in Dyeing Compositions | THE PROCTER & GAMBLE COMPANY (US) | 2013-08-22 | — | — | US | disclosed |
| US-8460397-B2 | Oxidative dyeing compositions comprising an 1-hexyl/heptyl-4,5-diaminopyrazole and a pyridine and derivatives thereof | THE PROCTER & GAMBLE COMPANY (US) | 2013-06-11 | — | — | US | disclosed |
| US-20120210526-A1 | Oxidative Dyeing Compositions Comprising an 1-Hexyl/Heptyl-4,5-diaminopyrazole and a Pyridine and Derivatives Thereof | WELLA OPERATIONS US, LLC | 2012-08-23 | — | — | US | disclosed |
| EP-2421501-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF | The Procter & Gamble Company (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123863-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120210526-A1 | Oxidative Dyeing Compositions Comprising an 1-Hexyl/Heptyl-4,5-diaminopyrazole and a Pyridine and Derivatives Thereof | KRT18, NOX4, AOC1 | TPMT 2813/4885ALDH1A1 169/4885SMN1; SMN2 3922/4885 |
| US-20140289973-A1 | 1-Hexyl-1H-Pyrazole-4,5-Diamine Hemisulfate, and Its Use in Dyeing Compositions | PPOX, XDH, DPYD | TPMT 544/4885ALDH1A1 210/4885SMN1; SMN2 4400/4885 |
| US-20130212810-A1 | 1-Hexzl-1H-Pyrazole-4,5-Diamine Hemisulfate, and Its Use in Dyeing Compositions | PPOX, XDH, TYR | TPMT 465/4885ALDH1A1 283/4885SMN1; SMN2 4718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.