Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133144 | 0.93 | RAB9A (0.48) | SMN1; SMN2KDM4ESCDNAMPTGAA | |
| SCHEMBL6133196 | 0.90 | L3MBTL1 (0.40) | SMN1; SMN2KDM4ETDP1NAMPTTP53 | |
| SCHEMBL6133345 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ESCDNAMPTPOLB | |
| SCHEMBL6133161 | 0.84 | L3MBTL1 (0.47) | SMN1; SMN2SCDPOLBALDH1A1LMNA | |
| SCHEMBL6133423 | 0.83 | MMP13 (0.43) | SMN1; SMN2SCDNAMPTALDH1A1LMNA | |
| SCHEMBL6133569 | 0.83 | HDAC6 (0.45) | SMN1; SMN2KDM4ENAMPTGAARAB9A | |
| SCHEMBL6133260 | 0.83 | P2RX3 (0.43) | SCD | |
| SCHEMBL6133040 | 0.81 | GABRA5 (0.40) | KDM4EGAARAB9AALDH1A1TSHR | |
| SCHEMBL6133208 | 0.80 | NAMPT (0.49) | SMN1; SMN2KDM4ESCDNAMPTRAB9A | |
| SCHEMBL6134790 | 0.80 | TGFBR1 (0.41) | SMN1; SMN2KDM4ETDP1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |