Citric Acid

Citric Acid

SCHEMBL693006

O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Fe+3].[Mn+2].[Mn+2].[Mn+2]

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BHRH2IMPA1

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CA4 P22748 3/20 0.89
ALDH1A1 P00352 1/20 0.33
CASP1 P29466 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL362816 1.00 CA4 (0.89) CA4ALDH1A1CASP1
Citric Acid SCHEMBL18131942 1.00 CA4 (0.89) CA4ALDH1A1CASP1
Citric Acid SCHEMBL30350220 0.97 CA4 (0.94) CA4ALDH1A1CASP1
Citric Acid SCHEMBL32679845 0.97 CA4 (0.84) CA4ALDH1A1CASP1
Citric Acid SCHEMBL2335912 0.97 CA4 (0.84) CA4ALDH1A1CASP1
Citric Acid SCHEMBL31633755 0.97 CA4 (0.84) CA4ALDH1A1CASP1
Citric Acid SCHEMBL31413937 0.97 CA4 (0.84) CA4ALDH1A1CASP1
Citric Acid SCHEMBL22686437 0.97 CA4 (0.94) CA4ALDH1A1CASP1
Citric Acid SCHEMBL29587574 0.97 CA4 (0.94) CA4ALDH1A1CASP1
Citric Acid SCHEMBL1291555 0.97 CA4 (0.94) CA4ALDH1A1CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021137780-A1 PREPARATION OF FILM TABLET COMPOSITION COMPRISING HEME IRON FOR IRON DEFICIENCY İLKO İLAÇ SANAYİ VE TİCARET A.Ş. (TR) 2021-07-08 WO claimed
US-9913806-B2 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron FE3 MEDICAL, INC. (US) 2018-03-13 US claimed
US-9731982-B2 Surface modified ceramic filter UNIVERSITY OF KANSAS (US) 2017-08-15 US claimed
EP-3103510-A1 SYSTEM FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS Incube Labs, Llc (US) 2016-12-14 EP claimed
EP-2320885-B1 PATCHES FOR THE TRANSDERMAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF IRON FE3 MEDICAL INC (US) 2016-10-19 EP claimed
EP-2421601-B1 SYSTEM FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS INCUBE LABS LLC (US) 2016-06-15 EP claimed
US-20130341281-A1 Surface Modified Ceramic Filter UNIVERSITY OF KANSAS (US) 2013-12-26 US claimed
WO-2013075018-A1 SURFACE MODIFIED CERAMIC FILTER UNIVERSITY OF KANSAS (US) 2013-05-23 WO claimed
WO-2012092305-A2 NANONIZED IRON COMPOSITIONS AND METHODS OF USE THEREOF INCUBE LABS, LLC (US) 2012-07-05 WO claimed
EP-2421601-A2 METHOD FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS Incube Labs, Llc (US) 2012-02-29 EP claimed
WO-2010123584-A2 METHOD FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS INCUBE LABS, LLC (US) 2010-10-28 WO claimed
US-20090035385-A1 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2009-02-05 US claimed
EP-1827418-A2 COMPOSITIONS INCLUDING IRON Drugtech Corporation (US) 2007-09-05 EP claimed
EP-1827419-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION Drugtech Corporation (US) 2007-09-05 EP claimed
WO-2006068697-A2 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
WO-2006068729-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
US-20060134227-A1 Compositions including iron DRUGTECH CORPORATION 2006-06-22 US claimed
WO-2003086321-A2 MODIFIED RELEASE MINERALS DRUGTECH CORPORATION (US) 2003-10-23 WO claimed
US-20030190355-A1 Modified release minerals DRUGTECH CORPORATION 2003-10-09 US claimed
US-12016906-B2 Pharmaceutical composition for anaemia FRIMLINE PRIVATE LIMITED (IN) 2024-06-25 US disclosed
US-11969398-B2 Methods, compositions, and devices for making sustained biodegradable implants in tissue PATHAK HOLDINGS LLC (US) 2024-04-30 US disclosed
CN-116636620-A Black egg white peptide composition and application thereof 南昌大学 2023-08-25 CN disclosed
WO-2023119230-A1 COAGULATION PATHWAY AND NICOTINAMIDE-ADENINE DINUCLEOTIDE PATHWAY MODULATING COMPOSITIONS AND METHODS OF THEIR USE L'OREAL (FR) 2023-06-29 WO disclosed
EP-3661373-B1 A PHARMACEUTICAL COMPOSITION FOR ANAEMIA FRIMLINE PRIVATE LTD (IN) 2022-06-22 EP disclosed
US-20220160830-A1 COMPOSITIONS COMPRISING CHOLINE JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT 2022-05-26 US disclosed
US-20210275472-A1 METHODS, COMPOSITIONS, AND DEVICES FOR DRUG / LIVE CELL MICROARRAYS PATHAK HOLDINGS LLC 2021-09-09 US disclosed
WO-2021137780-A1 PREPARATION OF FILM TABLET COMPOSITION COMPRISING HEME IRON FOR IRON DEFICIENCY İLKO İLAÇ SANAYİ VE TİCARET A.Ş. (TR) 2021-07-08 WO disclosed
US-11045433-B2 Method of making an in situ sustained biodegradable drug delivery implant by filling an artificial tissue cavity PATHAK HOLDINGS LLC (US) 2021-06-29 US disclosed
US-20200405822-A1 A PHARMACEUTICAL COMPOSITION FOR ANAEMIA FRIMLINE PRIVATE LIMITED (IN) 2020-12-31 US disclosed
US-20200230081-A1 METHODS, COMPOSITIONS, AND DEVICES FOR DRUG / LIVE CELL MICROARRAYS PATHAK HOLDINGS LLC 2020-07-23 US disclosed
EP-3661373-A1 A PHARMACEUTICAL COMPOSITION FOR ANAEMIA Frimline Private Limited (IN) 2020-06-10 EP disclosed
US-10624865-B2 Methods, compositions, and devices for drug/live cell microarrays PATHAK HOLDINGS LLC (US) 2020-04-21 US disclosed
US-10463629-B2 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron FE3 MEDICAL, INC. (US) 2019-11-05 US disclosed
WO-2019171236-A1 A PHARMACEUTICAL COMPOSITION FOR ANAEMIA FRIMLINE PRIVATE LIMITED (IN) 2019-09-12 WO disclosed
US-20190125828-A1 COMPOSITIONS COMPRISING CHOLINE JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT 2019-05-02 US disclosed
US-20190046479-A1 METHODS, COMPOSITIONS, AND DEVICES FOR DRUG / LIVE CELL MICROARRAYS PATHAK HOLDINGS LLC 2019-02-14 US disclosed
EP-3432870-A1 COMPOSITIONS COMPRISING CHOLINE Balchem Corporation (US) 2019-01-30 EP disclosed
EP-2709714-B1 APPARATUS FOR HEATING A TREATMENT REGION WITH AN ALTERNATING ELECTRIC FIELD INNOVOLINK LLC (US) 2019-01-16 EP disclosed
US-20180333367-A1 Patches and Methods for the Transdermal Delivery of a Therapeutically Effective Amount of Iron FE2, INC. 2018-11-22 US disclosed
US-9956028-B2 Apparatus and method for heating biological targets INNOVOLINK, LLC (US) 2018-05-01 US disclosed
US-9913806-B2 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron FE3 MEDICAL, INC. (US) 2018-03-13 US disclosed
US-9901742-B2 Apparatus and method for heating a treatment region with an alternating electric field INNOVOLINK, LLC (US) 2018-02-27 US disclosed
US-9901387-B2 Apparatus and method for heating adipose cells INNOVOLINK, LLC (US) 2018-02-27 US disclosed
WO-2018017674-A1 METHODS, COMPOSITIONS, AND DEVICES FOR DRUG / LIVE CELL MICROARRAYS PATHAK HOLDINGS, LLC (US) 2018-01-25 WO disclosed
WO-2017165287-A1 COMPOSITIONS COMPRISING CHOLINE BALCHEM CORPORATION (US) 2017-09-28 WO disclosed
US-9731982-B2 Surface modified ceramic filter UNIVERSITY OF KANSAS (US) 2017-08-15 US disclosed
US-20170189447-A1 FORMULATION FOR INCREASING ENERGY NIS Clinical Research (US) 2017-07-06 US disclosed
US-9675814-B2 Apparatus and method for obtaining a substantially constant current across a treatment region INNOVOLINK, LLC (US) 2017-06-13 US disclosed
US-9670080-B2 Composition and method for treating oilfield water BAKER HUGHES INCORPORATED (US) 2017-06-06 US disclosed
EP-3103510-A1 SYSTEM FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS Incube Labs, Llc (US) 2016-12-14 EP disclosed
EP-2320885-B1 PATCHES FOR THE TRANSDERMAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF IRON FE3 MEDICAL INC (US) 2016-10-19 EP disclosed
EP-2421601-B1 SYSTEM FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS INCUBE LABS LLC (US) 2016-06-15 EP disclosed
US-20160022631-A1 Methods and Compositions for Enhancing Iron Absorption LUMARA HEALTH IP LTD (US) 2016-01-28 US disclosed
US-20150258035-A1 Patches and Methods for the Transdermal Delivery of a Therapeutically Effective Amount of Iron FE2, INC. 2015-09-17 US disclosed
US-8996104-B2 Patches and method for the transdermal delivery of a therapeutically effective amount of iron FE3 MEDICAL, INC. (US) 2015-03-31 US disclosed
US-20140374104-A1 COMPOSITION AND METHOD FOR TREATING OILFIELD WATER BAKER HUGHES INCORPORATED (US) 2014-12-25 US disclosed
US-8821945-B2 Method for transdermal iontophoretic delivery of chelated agents FE3 MEDICAL, INC. (US) 2014-09-02 US disclosed
US-8802114-B2 Pharmaceutical compositions of iron for oral administration MERRION RESEARCH III LIMITED (IE) 2014-08-12 US disclosed
US-20140134290-A1 ANIMAL FEED ADDITIVES Inco Digestive, Inc. (US) 2014-05-15 US disclosed
EP-2709714-A1 APPARATUS AND METHOD FOR HEATING A TREATMENT REGION WITH AN ALTERNATING ELECTRIC FIELD Innovolink, LLC (US) 2014-03-26 EP disclosed
US-20130341281-A1 Surface Modified Ceramic Filter UNIVERSITY OF KANSAS (US) 2013-12-26 US disclosed
CN-103476419-A Pharmaceutical compositions of iron for oral administration MERRION RES III LTD 2013-12-25 CN disclosed
EP-2661273-A2 PHARMACEUTICAL COMPOSITIONS OF IRON FOR ORAL ADMINISTRATION Merrion Research III Limited (IE) 2013-11-13 EP disclosed
US-20130189374-A1 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION DRUGTECH CORPORATION (US) 2013-07-25 US disclosed
WO-2013075018-A1 SURFACE MODIFIED CERAMIC FILTER UNIVERSITY OF KANSAS (US) 2013-05-23 WO disclosed
WO-2013012657-A1 ANIMAL FEED ADDITIVES INCO DIGESTIVE, LLC (US) 2013-01-24 WO disclosed
US-20130022706-A1 Animal Feed Additive INCO DIGESTIVE, LLC (US) 2013-01-24 US disclosed
WO-2012154736-A1 APPARATUS AND METHOD FOR HEATING A TREATMENT REGION WITH AN ALTERNATING ELECTRIC FIELD INNOVOLINK, LLC (US) 2012-11-15 WO disclosed
US-20120289955-A1 Apparatus and Method for Heating Biological Targets INNOVOLINK, LLC 2012-11-15 US disclosed
US-20120290049-A1 Apparatus and Method for Providing a Substantially Constant Voltage Between Electrodes Extending Across a Treatment Region INNOVOLINK, LLC 2012-11-15 US disclosed
US-20120290050-A1 Apparatus and Method for Obtaining a Substantially Constant Current Across a Treatment Region INNOVOLINK, LLC 2012-11-15 US disclosed
US-20120289956-A1 Apparatus and Method for Heating Adipose Cells INNOVOLINK, LLC 2012-11-15 US disclosed
US-20120290048-A1 Apparatus and Method for Heating a Treatment Region with an Alternating Electric Field INNOVOLINK, LLC 2012-11-15 US disclosed
US-20120189692-A1 Pharmaceutical Compositions of Iron for Oral Administration NOVO NORDISK A/S (DK) 2012-07-26 US disclosed
US-20120184894-A1 Patches and Methods for the Transdermal Delivery of Agents to Treat Hair Loss INCUBE LABS, LLC 2012-07-19 US disclosed
US-20120177700-A1 Nanonized Iron Compositions and Methods of Use Thereof FE3 MEDICAL, INC. 2012-07-12 US disclosed
WO-2012094598-A2 PHARMACEUTICAL COMPOSITIONS OF IRON FOR ORAL ADMINISTRATION MERRION RESEARCH III LIMITED (IE) 2012-07-12 WO disclosed
WO-2012092305-A2 NANONIZED IRON COMPOSITIONS AND METHODS OF USE THEREOF INCUBE LABS, LLC (US) 2012-07-05 WO disclosed
WO-2012092628-A2 PATCHES AND METHODS FOR THE TRANSDERMAL DELIVERY OF AGENTS TO TREAT HAIR LOSS INCUBE LABS, LLC (US) 2012-07-05 WO disclosed
EP-2421601-A2 METHOD FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS Incube Labs, Llc (US) 2012-02-29 EP disclosed
US-8080520-B2 Composition and method for treating iron deficiency anemia NURYA BRANDS, INC. 2011-12-20 US disclosed
EP-2320885-A1 PATCHES AND METHODS FOR THE TRANSDERMAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF IRON Fe3 Medical, Inc (US) 2011-05-18 EP disclosed
WO-2009158032-A9 PATCHES AND METHODS FOR THE TRANSDERMAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF IRON FE3 MEDICAL, INC (US) 2011-03-03 WO disclosed
US-20110015150-A1 METHODS OF ADMINISTERING COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2011-01-20 US disclosed
WO-2010123584-A2 METHOD FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS INCUBE LABS, LLC (US) 2010-10-28 WO disclosed
US-20100130912-A1 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron FE2, INC. 2010-05-27 US disclosed
US-20100129496-A1 NUTRITIONAL FORMULATIONS DRUGTECH CORPORATION (US) 2010-05-27 US disclosed
US-20100130910-A1 Patches and method for the transdermal delivery of a therapeutically effective amount of iron FE2, INC. 2010-05-27 US disclosed
US-20100112676-A1 ODOR CONTROL METHODS AND COMPOSITIONS COATES JOHN D 2010-05-06 US disclosed
WO-2009158032-A1 PATCHES AND METHODS FOR THE TRANSDERMAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF IRON FE2, INC. (US) 2009-12-30 WO disclosed
US-20090281021-A1 Composition and Method for Treating Iron Deficiency Anemia NURYA BRANDS, INC. 2009-11-12 US disclosed
US-7585527-B2 Composition and method for treating iron deficiency anemia NURYA BRANDS, INC. 2009-09-08 US disclosed
WO-2009032699-A1 ANTI-PROLIFERATIVE COMBINATIONS DRUGTECH CORPORATION (US) 2009-03-12 WO disclosed
US-20090068190-A1 ANTI-PROLIFERATIVE COMBINATIONS DRUGTECH CORPORATION (US) 2009-03-12 US disclosed
US-20090035385-A1 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2009-02-05 US disclosed
US-20090028962-A1 Methods and Compositions for Enhancing Iron Absorption DRUGTECH CORPORATION (US) 2009-01-29 US disclosed
EP-1750682-A4 NUTRITIONAL FORMULATIONS DRUGTECH CORP (US) 2008-10-22 EP disclosed
WO-2008100767-A1 COMPOSITIONS FOR IMPROVING GASTROINTESTINAL NUTRIENT AND DRUG ABSORPTION DRUGTECH CORPORATION (US) 2008-08-21 WO disclosed
US-20080193531-A1 COMPOSITIONS FOR IMPROVING GASTROINTESTINAL NUTRIENT AND DRUG ABSORPTION DRUGTECH CORPORATION (US) 2008-08-14 US disclosed
EP-1827418-A2 COMPOSITIONS INCLUDING IRON Drugtech Corporation (US) 2007-09-05 EP disclosed
EP-1827419-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION Drugtech Corporation (US) 2007-09-05 EP disclosed
WO-2007035757-A2 COMPOSITION AND METHOD FOR TREATING IRON DEFICIENCY ANEMIA VENKATARAMAN BALA (US) 2007-03-29 WO disclosed
US-20070065521-A1 Composition and method for treating iron deficiency anemia NURYA BRANDS, INC. 2007-03-22 US disclosed
US-20070059815-A1 Odor control methods and compositions BOARD OF TRUSTEES AT SOUTHERN ILLINOIS UNIVERSITY 2007-03-15 US disclosed
EP-1750682-A2 NUTRITIONAL FORMULATIONS Drugtech Corporation (US) 2007-02-14 EP disclosed
WO-2006068697-A2 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2006-06-29 WO disclosed
WO-2006068729-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION DRUGTECH CORPORATION (US) 2006-06-29 WO disclosed
US-20060134227-A1 Compositions including iron DRUGTECH CORPORATION 2006-06-22 US disclosed
WO-2005120524-A2 NUTRITIONAL FORMULATIONS DRUGTECH CORPORATION (US) 2005-12-22 WO disclosed
US-20050037065-A1 NUTRITIONAL FORMULATIONS DRUGTECH CORPORATION (US) 2005-02-17 US disclosed
WO-2003086321-A2 MODIFIED RELEASE MINERALS DRUGTECH CORPORATION (US) 2003-10-23 WO disclosed
US-20030190355-A1 Modified release minerals DRUGTECH CORPORATION 2003-10-09 US disclosed
EP-0299942-B1 ANTIFREEZE COMPOSITION NIPPON SHOKUBAI CO., LTD. (JP) 1992-12-02 EP disclosed
US-5080818-A Antifreeze composition NIPPON SHOKUBAI KAGAKU KOGYO CO., LTD. (JP) 1992-01-14 US disclosed
EP-0299942-A2 Antifreeze composition NIPPON SHOKUBAI CO., LTD. (JP) 1989-01-18 EP disclosed
EP-0299942-A2 Antifreeze composition NIPPON SHOKUBAI CO., LTD. (JP) 1989-01-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170189447-A1 FORMULATION FOR INCREASING ENERGY COQ8A, COQ8B, NDUFS6 CA4 3260/4885ALDH1A1 2945/4885CASP1 4425/4885
US-20090068190-A1 ANTI-PROLIFERATIVE COMBINATIONS FOLR2, FOLR1, DHFR CA4 3988/4885ALDH1A1 1172/4885CASP1 1282/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.