Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 6/20 | 0.64 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TMPRSS4 | Q9NRS4 | 5/20 | 0.53 |
| ▸ | PNLIP | P16233 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10428048 | 0.80 | P2RX1 (0.57) | P2RX1TMPRSS4PNLIPNPC1RAB9A | |
| SCHEMBL29454776 | 0.78 | P2RX1 (1.00) | P2RX1TMPRSS4P2RX4P2RX7KCNMA1 | |
| SCHEMBL2169619 | 0.78 | P2RX1 (1.00) | P2RX1TMPRSS4P2RX4P2RX7KCNMA1 | |
| SCHEMBL15313832 | 0.78 | BCL2L1 (0.63) | P2RX1KLKB1ALOX15ALDH1A1LMNA | |
| SCHEMBL21914835 | 0.77 | P2RX1 (0.62) | P2RX1KLKB1PNLIPNPC1RAB9A | |
| SCHEMBL15313831 | 0.75 | GPR27 (0.61) | P2RX1GAAKMT2A | |
| SCHEMBL2698725 | 0.75 | PNLIP (0.82) | P2RX1ALOX15TMPRSS4PNLIPPLAU | |
| SCHEMBL7116292 | 0.75 | P2RX1 (0.56) | P2RX1PNLIPNPC1LMNAKMT2A | |
| SCHEMBL10885167 | 0.74 | PLG (0.71) | P2RX1ALOX15P2RX4P2RX7PLG | |
| SCHEMBL24460276 | 0.73 | P2RX1 (0.77) | P2RX1TMPRSS4PLAUP2RX4P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100486-A4 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1100486-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006147-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |