Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR27 | Q9NS67 | 12/20 | 0.61 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.61 |
| ▸ | TUBB | P07437 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.55 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.55 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313832 | 0.88 | BCL2L1 (0.63) | GPR27AVPR2MEN1KMT2AP2RX1 | |
| SCHEMBL15313830 | 0.80 | GPR27 (0.61) | GPR27AVPR2MEN1KMT2A | |
| SCHEMBL15313834 | 0.77 | ALOX12 (0.54) | GPR27AVPR2KMT2A | |
| SCHEMBL15313835 | 0.76 | CA12 (0.51) | GPR27AVPR2MEN1KMT2AKDM4E | |
| SCHEMBL2474197 | 0.75 | CES1 (1.00) | MEN1KMT2ACES1TDP1GAA | |
| SCHEMBL6554630 | 0.75 | CES1 (1.00) | MEN1KMT2ACES1TDP1GAA | |
| SCHEMBL6930179 | 0.75 | P2RX1 (0.64) | KMT2AP2RX1GAA | |
| SCHEMBL6754585 | 0.75 | SLC10A6 (0.81) | GPR27AVPR2MEN1KMT2ASLC10A2 | |
| SCHEMBL17593181 | 0.75 | KMT2A (0.92) | GPR27AVPR2MEN1KMT2ATDP1 | |
| SCHEMBL27180609 | 0.74 | GPR27 (0.78) | GPR27AVPR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |