Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | GRB2 | P62993 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | TPH1 | P17752 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934218 | 0.85 | PTPN1 (0.43) | PTPN1SLC7A5ITGB3ITGA2BALPI | |
| Phenylalanine SCHEMBL7906184 | 0.85 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL6935180 | 0.84 | DPP4 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL7906161 | 0.84 | GRB2 (0.47) | PTPN1SLC7A5ALPIPKMPTGS1 | |
| SCHEMBL6931447 | 0.83 | CTSL (0.40) | PTPN1SLC7A5ALPIPKMPTGS1 | |
| SCHEMBL7904116 | 0.83 | SLC7A5 (0.45) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL6934867 | 0.83 | LTA4H (0.39) | PTPN1TPH1DPP4DPP8DPP7 | |
| SCHEMBL7905125 | 0.83 | ITGB1 (0.43) | PTPN1ACACBSLC7A5ITGB3ITGA2B | |
| SCHEMBL6936891 | 0.83 | S1PR5 (0.47) | PTPN1ACACBSLC7A5ITGB3ITGA2B | |
| SCHEMBL7906163 | 0.82 | L3MBTL1 (0.36) | SLC7A5ITGB3ITGA2BALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984981-B1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LTD (GB) | 2003-12-17 | — | — | EP | disclosed |
| US-6093696-A | N-ACETYL-D-THIOPROLINE-(O-2,6-DICHLOROBENZYL)-L-TYROSINE, FOR EXAMPLE; SELECTIVELY INHIBIT THE ALPHA 4 SUBGROUP OF INTEGRINS FROM BINDING TO THEIR LIGANDS; USE IN PROPHYLAXIS OR TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |