Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | HTR3A | P46098 | 3/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.47 |
| ▸ | HTR3B | O95264 | 2/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933017 | 0.82 | POLB (0.56) | HTR6ADRB1HTTMEN1KMT2A | |
| SCHEMBL6932177 | 0.80 | SIGMAR1 (0.52) | SLC6A4SLC6A2HTR3ASIGMAR1CYP2C9 | |
| SCHEMBL6931860 | 0.76 | BRS3 (0.48) | SLC6A4SLC6A2SIGMAR1HTR2AHTR2C | |
| SCHEMBL9322314 | 0.75 | KDM4E (0.49) | SLC6A4SLC6A2HTR6HTR3ASIGMAR1 | |
| SCHEMBL27918650 | 0.75 | SIGMAR1 (0.46) | SLC6A4SLC6A2SIGMAR1MEN1KMT2A | |
| SCHEMBL542956 | 0.74 | ENPP2 (0.53) | SLC6A4SLC6A2HTR6HTR3ASIGMAR1 | |
| SCHEMBL29478520 | 0.74 | SIGMAR1 (0.72) | SLC6A4SLC6A2HTR6SIGMAR1CYP2C9 | |
| SCHEMBL1888148 | 0.74 | SIGMAR1 (0.72) | SLC6A4SLC6A2HTR6SIGMAR1CYP2C9 | |
| Hydrochloric Acid SCHEMBL4819656 | 0.73 | SIGMAR1 (0.70) | HTR6SIGMAR1CYP2C9CYP2C19HTT | |
| SCHEMBL9397258 | 0.72 | SIGMAR1 (0.65) | SLC6A4SLC6A2HTR6HTR3ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366030-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | Neurogen Corporation (US) | 2003-12-03 | — | — | EP | claimed |
| WO-2002004433-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-17 | — | — | WO | claimed |