Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931992 | 0.80 | CYP19A1 (0.40) | CYP19A1LMNAALDH1A1 | |
| SCHEMBL6930525 | 0.80 | POLB (0.37) | CYP19A1MAPTALDH1A1 | |
| SCHEMBL6932378 | 0.76 | CNR2 (0.37) | SMN1; SMN2 | |
| SCHEMBL8180505 | 0.76 | CYP19A1 (0.42) | CYP19A1MAPTALDH1A1TBXA2RSLC6A2 | |
| SCHEMBL6935322 | 0.75 | CYP19A1 (0.39) | CYP19A1MAPTLMNAHTTVCAM1 | |
| SCHEMBL6342196 | 0.75 | CYP19A1 (0.37) | CYP19A1MAPTTBXA2RSLC6A2SLC6A4 | |
| SCHEMBL6935009 | 0.69 | CYP19A1 (0.39) | CYP19A1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6938882 | 0.68 | CYP3A4 (0.44) | MAPTLMNAALDH1A1SMN1; SMN2ADRA2A | |
| SCHEMBL9156355 | 0.68 | HIF1A (0.46) | MAPTLMNAALDH1A1SMN1; SMN2PNMT | |
| SCHEMBL6936617 | 0.68 | KCNE1 (0.53) | LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915087-B1 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-04-02 | — | — | EP | disclosed |
| US-6015822-A | ANTIULCER, ANTIDIARRHEA, AND ANTIARRHYTHMIA AGENTS; CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-01-18 | — | — | US | disclosed |
| EP-0915087-A2 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-12 | — | — | EP | disclosed |