Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104780 | 0.81 | P2RX7 (0.45) | CNR2MEN1KMT2AFAAHEPHX2 | |
| SCHEMBL8104812 | 0.73 | HSP90AA1 (0.37) | CNR2MEN1KMT2AFAAHEPHX2 | |
| SCHEMBL8104976 | 0.69 | KDM4E (0.36) | EPHX2P2RX7 | |
| SCHEMBL8095608 | 0.68 | KDM4E (0.38) | MEN1KMT2AEPHX2P2RX7 | |
| SCHEMBL5805025 | 0.64 | P2RX7 (0.47) | CNR2MEN1KMT2AEPHX2P2RX7 | |
| SCHEMBL6941160 | 0.61 | P2RX7 (0.67) | KMT2AEPHX2P2RX7 | |
| SCHEMBL7570486 | 0.60 | P2RX7 (0.64) | MEN1KMT2AP2RX7RECQL | |
| SCHEMBL23040781 | 0.59 | ALDH1A1 (0.39) | MEN1KMT2AEPHX2 | |
| SCHEMBL11640397 | 0.59 | ALDH1A1 (0.44) | CNR2MEN1KMT2AFAAH | |
| SCHEMBL16248317 | 0.59 | EPHX2 (0.49) | CNR2MEN1KMT2AFAAHEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |